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Oral administration of Lactobacillus brevis KB290 to mice alleviates clinical symptoms following influenza virus infection
It is demonstrated that oral administration of KB290 before infection could alleviate IFV‐induced clinical symptoms, which may have been induced by long‐lasting enhancement of IFN‐α production and the augmentation ofIFV‐specific IgA production. Expand
In vivo transgenic mutation assays
Transgenic rodent gene mutation models provide quick and statistically reliable assays for mutations in the DNA from any tissue, and Sequencing data would not normally be required but might provide useful additional information in specific circumstances. Expand
In vivo transgenic mutation assays.
A general protocol was agreed in which animals are treated daily for 28 consecutive days and tissues sampled 3 days after the final treatment, which could be modified by reducing or increasing the number of treatments or the length of the treatment period, when scientifically justified. Expand
Evaluation of the rodent micronucleus assay by a 28‐day treatment protocol: Summary of the 13th Collaborative Study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Environmental
Rats can provide biologically important and relevant information regarding potential chemical mutagens that can be evaluated under conditions used in the conduct of general toxicology studies, and the integration of the micronucleus assay into a 28‐day toxicological assay is feasible. Expand
Genomic Analysis by Deep Sequencing of the Probiotic Lactobacillus brevis KB290 Harboring Nine Plasmids Reveals Genomic Stability
Deep sequencing of four periodic KB290 culture stocks with more than 1,000-fold coverage revealed 3 mutation sites and 37 minority variation sites, indicating long-term stability and providing a useful method for assessing the stability of industrial bacteria at the nucleotide level. Expand
Assessment of antibiotic resistance in probiotic strain Lactobacillus brevis KB290.
This study demonstrated that the antibiotic resistance observed in L. brevis KB290 was due not to dedicated mechanisms but to intrinsic resistance, providing safety assurance for the ongoing use of the strain as a probiotic. Expand
A novel macromolecular antibiotic, SN-07. Taxonomy of producing organism, isolation, characterization and biological activities.
A novel macromolecular antibiotic SN-07 was obtained from the cultural supernatant of Actinomadura roseoviolacea var. miuraensis nov. var. The antibiotic was soluble in water, had a molecular weightExpand
Isolation stress for 30 days alters hepatic gene expression profiles, especially with reference to lipid metabolism in mice.
It is suggested that isolation for 30 days with a mild and consecutive social stress regulates the systems for lipid metabolism and also causes endoplasmic reticulum stress in mouse liver. Expand
Assessment of Antibiotic Resistance in Probiotic Lactobacilli
It is essential to thoroughly investigate the safety of lactobacilli used in probiotic products to fully investigate the beneficial effects of probiotic strains in promoting gut and general health. Expand