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The genetic and immunopathological processes underlying collagen‐induced arthritis
Animal models of rheumatoid arthritis (RA) have provided substantial insights into basic pathogenic mechanisms of chronic inflammatory arthritis and autoimmune disease in general. Of the variety ofExpand
Potent immunogenicity of the B subunits of Escherichia coli heat-labile enterotoxin: receptor binding is essential and induces differential modulation of lymphocyte subsets.
The importance of receptor binding in the potent immunogenicity of Escherichia coli heat-labile enterotoxin B subunit (EtxB) was tested by comparing its immunogical properties with those of aExpand
Immune modulation by the cholera-like enterotoxins: from adjuvant to therapeutic.
Cholera toxin and its close relative, Escherichia coli heat-labile enterotoxin, are potent immunogens and mucosal adjuvants. The recent findings that their B subunits can promote tolerance highlightsExpand
Cytokine production in the nervous system of mice during acute and latent infection with herpes simplex virus type 1.
Immunocytochemistry on serial paraffin sections was used to monitor the production dynamics of cytokines (IL-2, IL-4, IL-6, IL-10, IFN-gamma and TNF-alpha) and viral antigens in the trigeminalExpand
Defective pneumococcal-specific Th1 responses in HIV-infected adults precedes a loss of control of pneumococcal colonization.
BACKGROUND African adults infected with human immunodeficiency virus (HIV) have high rates of pneumococcal colonization and invasive disease. Here we have investigated the possibility that HIVExpand
Immunohistochemical detection of T-cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies.
We describe a method for immunohistochemical localization of T-cells, CD4+ T-cells, CD8+ T-cells, B-cells, activated lymphocytes, major histocompatibility complex (MHC) class II antigens,Expand
Modulation of B‐cell activation by the B subunit of Escherichia coli enterotoxin: receptor interaction up‐regulates MHC class II, B7, CD40, CD25 and ICAM‐1
The B subunits of cholera toxin (CtxB) and Escherichia coli heat‐labile enterotoxin (EtxB) are non‐toxic lectins that bind and cross‐link a ubiquitous cell glycolipid receptor, ganglioside GM1, andExpand
Biofilm formation by Helicobacter pylori
Helicobacter pylori NCTC 11637 produces a water‐insoluble biofilm when grown under defined conditions with a high carbon:nitrogen ratio in continuous culture and in 10% strength Brucella brothExpand
Mutant Escherichia coli Heat-Labile Toxin B Subunit That Separates Toxoid-Mediated Signaling and Immunomodulatory Action from Trafficking and Delivery Functions
ABSTRACT The homopentameric B-subunit components of Escherichia coli heat-labile enterotoxin (EtxB) and cholera toxin (CtxB) possess the capacity to enter mammalian cells and to activateExpand
A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity
GM1-ganglioside receptor binding by the B subunit of cholera toxin (CtxB) is widely accepted to initiate toxin action by triggering uptake and delivery of the toxin A subunit into cells. MoreExpand