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Relation Between Alkaline Phosphatase, Serum Phosphate, and All-Cause or Cardiovascular Mortality
Background— Higher levels of serum alkaline phosphatase (AlkP) are associated with excess mortality in dialysis patients, but whether AlkP is associated with adverse outcomes among people without… Expand
Assessment of Global Kidney Health Care Status
Importance Kidney disease is a substantial worldwide clinical and public health problem, but information about available care is limited. Objective To collect information on the current state of… Expand
Graduated driver licensing for reducing motor vehicle crashes among young drivers.
- L. Hartling, N. Wiebe, K. Russell, J. Petruk, C. Spinola, T. Klassen
- The Cochrane database of systematic reviews
BACKGROUND Graduated driver licensing (GDL) has been proposed as a means of reducing crash rates among novice drivers by gradually introducing them to higher risk driving situations. OBJECTIVES To… Expand
Comparison of Clinical Outcomes and Adverse Events Associated With Glucose-Lowering Drugs in Patients With Type 2 Diabetes: A Meta-analysis.
IMPORTANCE Numerous glucose-lowering drugs are used to treat type 2 diabetes. OBJECTIVE To estimate the relative efficacy and safety associated with glucose-lowering drugs including insulin. DATA… Expand
Methods for identifying 30 chronic conditions: application to administrative data
- M. Tonelli, N. Wiebe, +10 authors H. Quan
- Medicine, Computer Science
- BMC Medical Informatics and Decision Making
- 17 April 2015
We identified a panel of 30 chronic conditions that can be identified from administrative data using validated algorithms, facilitating the study and surveillance of multimorbidity in Alberta, Canada. Expand
Trace elements in hemodialysis patients: a systematic review and meta-analysis
BackgroundHemodialysis patients are at risk for deficiency of essential trace elements and excess of toxic trace elements, both of which can affect health. We conducted a systematic review to… Expand
Kidney stones and kidney function loss: a cohort study
- R. T. Alexander, B. Hemmelgarn, +6 authors M. Tonelli
- BMJ : British Medical Journal
- 30 August 2012
Objective To investigate whether the presence of kidney stones increase the risk of end stage renal disease (ESRD) or other adverse renal outcomes. Design A registry cohort study using validated… Expand
A systematic review identifies a lack of standardization in methods for handling missing variance data.
- N. Wiebe, B. Vandermeer, R. Platt, T. Klassen, D. Moher, N. Barrowman
- Journal of clinical epidemiology
- 1 April 2006
BACKGROUND AND OBJECTIVES To describe and critically appraise available methods for handling missing variance data in meta-analysis (MA). METHODS Systematic review. MEDLINE, EMBASE, Web of Science,… Expand
Cause of Death in Patients with Reduced Kidney Function.
- Stephanie Thompson, Matthew T. James, +4 authors M. Tonelli
- Journal of the American Society of Nephrology…
- 2 March 2015
Information on common causes of death in people with CKD is limited. We hypothesized that, as eGFR declines, cardiovascular mortality and mortality from infection account for increasing proportions… Expand
Comorbidity as a driver of adverse outcomes in people with chronic kidney disease.
Chronic kidney disease (CKD) is associated with poor outcomes, perhaps due to a high burden of comorbidity. Most studies of CKD populations focus on concordant comorbidities, which cause CKD (such as… Expand