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The role of infection in miscarriage
- Sevi Giakoumelou, N. Wheelhouse, K. Cuschieri, G. Entrican, S. Howie, A. Horne
- Biology, Medicine
- Human reproduction update
- 19 September 2015
Whether certain infections do increase miscarriage risk and whether screening of newly pregnant women for treatable infections would improve reproductive outcomes is questioned. Expand
The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle.
The data indicate that DLEC1 is a candidate tumor suppressor gene that plays an important role in the development and progression of hepatocellular carcinoma. Expand
Molecular detection of Chlamydophila abortus in post-abortion sheep at oestrus and subsequent lambing.
- M. Livingstone, N. Wheelhouse, S. Maley, D. Longbottom
- Medicine, Biology
- Veterinary microbiology
- 16 March 2009
The results, although not discounting the possibility of a chronic low level persistent infection in post-abortion ewes, suggest that the low levels of chlamydial DNA detected during the periovulation period and at lambing do not significantly impact on the epidemiology of EAE. Expand
Endemic and emerging chlamydial infections of animals and their zoonotic implications.
The aim of this review is to draw together the evidence for the role of the newly emerging chlamydial infections in livestock disease, the current understanding of their roles in human disease and the potential for zoonotic transmission. Expand
Immunity in the female sheep reproductive tract.
Comp comparative studies suggest that there are likely to be conserved innate immune sensory mechanisms that combine to limit infection in its early stages while shaping the adaptive response that leads to immunological memory and long-term protection. Expand
Psittacine beak and feather disease in a free-living ring-necked parakeet (Psittacula krameri) in Great Britain
- Ricardo C. C. Sa, A. Cunningham, +5 authors B. Lawson
- European Journal of Wildlife Research
- 28 January 2014
The ring-necked parakeet with marked feather abnormalities observed in an urban garden in London was euthanased and examined post mortem, and Histopathological examination of affected skin demonstrated BFDV-compatible lesions. Expand
Differential expression of hDAB2IPA and hDAB2IPB in normal tissues and promoter methylation of hDAB2IPA in hepatocellular carcinoma.
The data suggest that hDAB2IPA is the dominant isoform expressed in normal tissues and its expression is suppressed in HCC, consistent with its role as a tumor suppressor gene, mainly by promoter methylation. Expand
Intranasal Infection with Chlamydia abortus Induces Dose-Dependent Latency and Abortion in Sheep
Background Latency is a key feature of the animal pathogen Chlamydia abortus, where infection remains inapparent in the non-pregnant animal and only becomes evident during a subsequent pregnancy.… Expand
Chlamydia trachomatis Infection Increases Fallopian Tube PROKR2 via TLR2 and NFκB Activation Resulting in a Microenvironment Predisposed to Ectopic Pregnancy
- J. Shaw, G. Wills, +8 authors A. Horne
- Biology, Medicine
- The American journal of pathology
- 1 January 2011
It is proposed that ligation of tubal TLR2 and activation of NFκB by C. trachomatis leads to increased tubal PROKR2, thereby predisposing the tubal microenvironment to ectopic implantation. Expand
Expression of secretory leukocyte protease inhibitor and elafin in human fallopian tube and in an in-vitro model of Chlamydia trachomatis infection.
The data suggest that SLPI and elafin have a role in the innate immune defence of the Fallopian tube in infection and ectopic pregnancy. Expand