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Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na+/H+ exchanger, lowering of cytosolic Na+ and vasodilation
Aims/hypothesisSodium–glucose cotransporter 2 (SGLT2) inhibitors (SGLT2i) constitute a novel class of glucose-lowering (type 2) kidney-targeted agents. We recently reported that the SGLT2i… Expand
Inhibition of p38 MAPK Activation via Induction of MKP-1: Atrial Natriuretic Peptide Reduces TNF-&agr;–Induced Actin Polymerization and Endothelial Permeability
- A. Kiemer, N. Weber, R. Fürst, Nicole Bildner, Stefanie Kulhanek-Heinze, A. Vollmar
- Biology, Medicine
- Circulation research
- 3 May 2002
The atrial natriuretic peptide (ANP) is a cardiovascular hormone possessing antiinflammatory potential due to its inhibitory action on the production of inflammatory mediators, such as tumor necrosis… Expand
Induction of IkappaB: atrial natriuretic peptide as a regulator of the NF-kappaB pathway.
Atrial natriuretic peptide (ANP) was shown to possess anti-inflammatory potential due to its potency to inhibit the production of inflammatory mediators, such as TNF-alpha. The aim of this study was… Expand
Robust estimation of precision matrices under cellwise contamination
This paper combines pairwise covariance matrix estimation with recent regularisation routines currently used in bioinformatics and machine learning to produce an estimated precision matrix that is robust to moderate levels of cellwise contamination. Expand
Molecular Mechanisms Transducing the Anesthetic, Analgesic, and Organ-protective Actions of Xenon
The anesthetic properties of xenon have been known for more than 50 yr, and the safety and efficacy of xenon inhalational anesthesia has been demonstrated in several recent clinical studies. In… Expand
Desflurane Preconditioning Induces Time-dependent Activation of Protein Kinase C Epsilon and Extracellular Signal-regulated Kinase 1 and 2 in the Rat Heart In Vivo
- O. Toma, N. Weber, J. I. Wolter, D. Obal, B. Preckel, W. Schlack
- 1 December 2004
Background:Activation of protein kinase C epsilon (PKC-&egr;) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) are important for cardioprotection by preconditioning. The present study… Expand
Characterization of heme oxygenase 1 (heat shock protein 32) induction by atrial natriuretic peptide in human endothelial cells.
BACKGROUND Atrial natriuretic peptide (ANP) is a cardiovascular hormone possessing antiinflammatory and cytoprotective potential. The aim of this study was to characterize induction of heme oxygenase… Expand
The noble gas xenon induces pharmacological preconditioning in the rat heart in vivo via induction of PKC-epsilon and p38 MAPK.
Xenon is an anesthetic with minimal hemodynamic side effects, making it an ideal agent for cardiocompromised patients. We investigated if xenon induces pharmacological preconditioning (PC) of the rat… Expand
Impact of preconditioning protocol on anesthetic-induced cardioprotection in patients having coronary artery bypass surgery.
- J. Frässdorf, A. Borowski, +8 authors W. Schlack
- The Journal of thoracic and cardiovascular…
- 1 June 2009
OBJECTIVE Anesthetic preconditioning may contribute to the cardioprotective effects of sevoflurane in patients having coronary artery bypass surgery. We investigated whether 2 different sevoflurane… Expand
Hyperglycaemia blocks sevoflurane-induced postconditioning in the rat heart in vivo: cardioprotection can be restored by blocking the mitochondrial permeability transition pore.
- R. Huhn, A. Heinen, N. Weber, M. Hollmann, W. Schlack, B. Preckel
- British journal of anaesthesia
- 1 April 2008
BACKGROUND Recent studies showed that hyperglycaemia (HG) blocks anaesthetic-induced preconditioning. The influence of HG on anaesthetic-induced postconditioning (post) has not yet been determined.… Expand