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Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase
A major cause of aging is thought to result from the cumulative effects of cell loss over time. In yeast, caloric restriction (CR) delays aging by activating the Sir2 deacetylase. Here we show thatExpand
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Yin Yang 1 Is a Negative Regulator of p53
Yin Yang 1 (YY1) is a transcription factor that plays an essential role in development. However, the full spectrum of YY1's functions and mechanism of action remains unclear. We find that YY1Expand
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Cancer gene therapy using a survivin mutant adenovirus.
We have constructed a replication-deficient adenovirus encoding a nonphosphorylatable Thr(34)-->Ala mutant of the apoptosis inhibitor survivin (pAd-T34A) to target tumor cell viability in vitro andExpand
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Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis.
Evasion of apoptosis is a hallmark of cancer, but the molecular circuitries of this process are not understood. Here we show that survivin, a member of the inhibitor of apoptosis gene family that isExpand
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A p34(cdc2) survival checkpoint in cancer.
A checkpoint surveying the entry into mitosis responds to defects in spindle microtubule assembly/stability. This has been used to trigger apoptosis in cancer cells, but how the spindle checkpointExpand
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Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function.
Survivin is a member of the inhibitor of apoptosis gene family that has been implicated in both apoptosis inhibition and regulation of mitosis. However, the subcellular distribution of survivin hasExpand
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Suppression of survivin phosphorylation on Thr34 by flavopiridol enhances tumor cell apoptosis.
Survivin is a member of the inhibitor of apoptosis gene family that is expressed in most human cancers and may facilitate evasion from apoptosis and aberrant mitotic progression. Here, exposure ofExpand
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Regulation of microtubule stability and mitotic progression by survivin.
Survivin is a member of the inhibitor of apoptosis (IAP) gene family, which has been implicated in both preservation of cell viability and regulation of mitosis in cancer cells. Here, we show thatExpand
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Plasma-Derived Exosomal Survivin, a Plausible Biomarker for Early Detection of Prostate Cancer
Background Survivin is expressed in prostate cancer (PCa), and its downregulation sensitizes PCa cells to chemotherapeutic agents in vitro and in vivo. Small membrane-bound vesicles called exosomes,Expand
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Combination antiangiogenic therapy and radiation in head and neck cancers.
Tumor angiogenesis is a hallmark of advanced cancers and promotes invasion and metastasis. Over 90% of head and neck squamous cell carcinomas (HNSCC) express angiogenic factors such as vascularExpand
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