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Experimental Pathogenesis for Chickens, Turkeys, and Pigeons of Exotic Newcastle Disease Virus from an Outbreak in California during 2002-2003
TLDR
Evidence of CA END virus subclinical infections that suggest pigeons could be subclinical carriers of other virulent NDV are provided, and susceptibility to highly virulentNDV was shown to vary among chickens, SPF turkeys, commercial turkeys and pigeons. Expand
The pathogenesis of Newcastle disease: a comparison of selected Newcastle disease virus wild-type strains and their infectious clones.
TLDR
Both pathogenicity indices and clinicopathologic examination demonstrated that the F, HN, and P genes of NDV collectively or individually can contribute to viral virulence. Expand
NLRC4 Inflammasome-Mediated Production of IL-1β Modulates Mucosal Immunity in the Lung against Gram-Negative Bacterial Infection
TLDR
It is reported that NLRC4 is important for host survival and bacterial clearance, as well as neutrophil-mediated inflammation in the lungs following Klebsiella pneumoniae infection, and exogenous IL-1β, but not IL-18 or IL-17A, partially rescued survival, neutrophils accumulation, and cytokine/chemokine expression in the lung of NLRC 4−/− mice following infectious challenge. Expand
Prevalence of and risk factors associated with atherosclerosis in psittacine birds.
TLDR
Age, female sex, and 3 genera appeared to be positively associated with the presence of advanced atherosclerotic lesions in psittacine birds, and this information may be useful in clinical assessment of the cardiovascular system and patient management. Expand
Both TRIF- and MyD88-Dependent Signaling Contribute to Host Defense against Pulmonary Klebsiella Infection1
TLDR
New insights are provided into the TRIF and MyD88 signaling triggered by pulmonary K. pneumoniae infection in the lungs and the therapeutic potential of MyD 88 in reducing excessive neutrophil influx in human disease during Gram-negative bacterial pneumonia is demonstrated. Expand
Recombinant vesicular stomatitis virus-based west Nile vaccine elicits strong humoral and cellular immune responses and protects mice against lethal challenge with the virulent west Nile virus strain
TLDR
The results suggest that VSV-vectored vaccines administered intranasally can efficiently induce protective humoral and cellular immune responses against WNV infections. Expand
Interleukin-12p40 Modulates Human Metapneumovirus-Induced Pulmonary Disease in an Acute Mouse Model of Infection
TLDR
It is demonstrated that in mice deficient in IL-12p40, h MPV infection induced an exacerbated pulmonary inflammatory response and mucus production, altered cytokine response, and decreased lung function, however, hMPV infection in these mice does not have an effect on viral replication. Expand
[DLys6]‐luteinizing hormone releasing hormone–curcumin conjugate inhibits pancreatic cancer cell growth in vitro and in vivo
TLDR
A bioconjugate of LHRH analog and a dietary microchemical (curcumin) is synthesized and test the hypothesis that it targets and inhibits pancreatic cancer cell growth in vitro and in vivo and concludes that [DLys6]‐LHRH–Curcumin may be useful in treating pancreaticcancer. Expand
Impact and Regulation of Lambda Interferon Response in Human Metapneumovirus Infection
TLDR
It is demonstrated that IFN-λ exhibited a protective role in hMPV infection in vitro and in an experimental mouse model of infection, which reduced the disease severity, lung viral titer, and inflammatory response in the lung. Expand
Experimental Diet-Induced Atherosclerosis in Quaker Parrots (Myiopsitta monachus)
TLDR
This experiment demonstrates that in Quaker parrots fed 1% cholesterol, advanced atherosclerosis can be induced relatively quickly, and lesions resemble those found in other avian models and humans. Expand
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