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Ultra high resolution SFC-MS (on sub-2μm particles) coupled to mass spectrometry has been evaluated for the metabolic profiling of rat and dog bile. The selectivity of the SFC separation differed(More)
The sensitivity and accuracy of a bioanalytical method is critical in defining the pharmacokinetic (PK) parameters of a potential new chemical entity (NCE). Inhaled therapeutics and low dose NCEs(More)