N. Velikova

Publications17
h-index7
Citations223
Highly Influential Citations3
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  • Publications
  • Influence
Bacterial histidine kinases as novel antibacterial drug targets.
Bacterial histidine kinases (HKs) are promising targets for novel antibacterials. Bacterial HKs are part of bacterial two-component systems (TCSs), the main signal transduction pathways in bacteria,… Expand
  • 84
  • 1
Superinduction of estrogen receptor mediated gene expression in luciferase based reporter gene assays is mediated by a post-transcriptional mechanism
Several estrogenic compounds including the isoflavonoid genistein have been reported to induce a higher maximal response than the natural estrogen 17β-estradiol in in vitro luciferase based reporter… Expand
  • 53
  • 1
Evaluation of Galleria mellonella larvae for studying the virulence of Streptococcus suis
BackgroundStreptococcus suis is an encapsulated Gram-positive bacterium and the leading cause of sepsis and meningitis in young pigs, resulting in considerable economic losses in the porcine… Expand
  • 18
  • 1
Putative histidine kinase inhibitors with antibacterial effect against multi-drug resistant clinical isolates identified by in vitro and in silico screens
Novel antibacterials are urgently needed to address the growing problem of bacterial resistance to conventional antibiotics. Two-component systems (TCS) are widely used by bacteria to regulate gene… Expand
  • 22
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Altered ivermectin pharmacology and defective visual system in Drosophila mutants for histamine receptor HCLB
The Drosophila gene hclB encodes a histamine-gated chloride channel, which can be activated by the neurotoxin ivermectin when expressed in vitro. We have identified two novel hclB mutants, carrying… Expand
  • 14
Broadening the antibacterial spectrum of histidine kinase autophosphorylation inhibitors via the use of ε-poly-L-lysine capped mesoporous silica-based nanoparticles.
Two-component systems (TCS) regulate diverse processes such as virulence, stress responses, metabolism and antibiotic resistance in bacteria but are absent in humans, making them promising targets… Expand
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WalK, the Path towards New Antibacterials with Low Potential for Resistance Development.
Resistance to antibiotics used in the treatment of bacterial infectious diseases is a global health problem. More than a decade ago, two-component systems such as WalKR were proposed as ideal targets… Expand
  • 10
An acidic model pro-peptide affects the secondary structure, membrane interactions and antimicrobial activity of a crotalicidin fragment
In order to study how acidic pro-peptides inhibit the antimicrobial activity of antimicrobial peptides, we introduce a simple model system, consisting of a 19 amino-acid long antimicrobial peptide,… Expand
  • 7
The VraSR regulatory system contributes to virulence in Streptococcus suis via resistance to innate immune defenses
Streptococcus suis is a microbe commonly present in pigs in many parts of the world. Usually S. suis does not cause disease neither in pigs, nor in humans. However, a number of outbreaks of S. suis… Expand
  • 3
Rationale and Prospects of Targeting Bacterial Two-component Systems for Antibacterial Treatment of Cystic Fibrosis Patients.
Bacterial respiratory infections are the main reason of morbidity and mortality among cystic fibrosis (CF) patients. In early childhood, the respiratory infections are due to Staphylococcus aureus… Expand
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