Estimation of glomerular filtration rate by the MDRD study equation modified for Japanese patients with chronic kidney disease
Although the Japanese coefficient improves the accuracy of G FR estimation of the original MDRD study equation, a new equation is needed for more accurate estimation of GFR in Japanese patients with CKD stages 3 and 4.
Prevalence of chronic kidney disease in the Japanese general population
The prevalence of CKD stages 1, 2, 3, and 4 + 5 were 0.6, 1.7, 10.7 and 0.2% in the study population, which resulted in predictions of 0.3% of the Japanese adult population—approximately 13.3 million people—were predicted to have CKD in 2005.
Prevalence of chronic kidney disease (CKD) in the Japanese general population predicted by the MDRD equation modified by a Japanese coefficient
About 20% of the Japanese adult population are predicted to have stage 3 to 5 CKD, as defined by a GFR of less than 60 ml/min per 1.73 m2, and the prevalence of concurrent CKD was significantly higher in hypertensive and diabetic populations than in the study population overall.
Urinary angiotensin-converting enzyme 2 in hypertensive patients may be increased by olmesartan, an angiotensin II receptor blocker.
- M. Furuhashi, N. Moniwa, T. Miura
- MedicineAmerican Journal of Hypertension
- 2015
In contrast with other antihypertensive drugs, olmesartan may uniquely increase urinary ACE2 level, which could potentially offer additional renoprotective effects.
Blockade of the Renin-Angiotensin System Increases Adiponectin Concentrations in Patients With Essential Hypertension
- M. Furuhashi, N. Ura, K. Shimamoto
- MedicineHYPERTENSION
- 1 July 2003
It is suggested that hypoadiponectinemia is related to insulin resistance in essential hypertension and that RAS blockade increases adiponectin concentrations with improvement in insulin sensitivity.
Strain rate imaging for noninvasive functional quantification of the left atrium: comparative studies in controls and patients with atrial fibrillation.
- Y. Inaba, S. Yuda, K. Shimamoto
- MedicineJournal of the American Society of…
- 1 July 2005
Olmesartan Is an Angiotensin II Receptor Blocker with an Inhibitory Effect on Angiotensin-Converting Enzyme
- J. Agata, N. Ura, K. Shimamoto
- BiologyHypertension Research
- 1 November 2006
It is suggested that olmesartan may exhibit an ACE inhibitory action in addition to an Ang II receptor blocking action, prevent an increase in Ang II level, and protect cardiovascular remodeling through an increased in cardiac nitric oxide production and endogenous Ang-(1-7) via over-expression of ACE2.
Slower Decline of Glomerular Filtration Rate in the Japanese General Population: A Longitudinal 10-Year Follow-Up Study
It is concluded that the decline in renal function progresses slowly in the Japanese general population, and Hypertension, proteinuria and lower GFR were found to be significant risk factors for a faster decline of GFR.
Blockade of the renin–angiotensin system decreases adipocyte size with improvement in insulin sensitivity
- M. Furuhashi, N. Ura, K. Shimamoto
- Medicine, BiologyJournal of Hypertension
- 1 October 2004
RAS blockade decreases adipocyte size without change in epididymal %fat pads accompanied by improvement in insulin sensitivity, thereby improving insulin sensitivity in fructose-fed rats as a model of insulin-resistant hypertension.
Role of renal endopeptidase 24.11 in kinin metabolism in vitro and in vivo.
- N. Ura, O. Carretero, E. G. Erdös
- Biology, MedicineKidney International
- 1 October 1987
The first demonstration of NEP having a major role in the catabolism of kinins is demonstrated, and the increase in UNaV and UV after phosphoramidon administration may be due to the inhibition of intrarenal kinin destruction.
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