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A Randomized Trial of Prenatal Versus Postnatal Repair of Myelomeningocele
Spina bifida is the most common of congenital central nervous system abnormalities that are compatible with life. The most frequent type of neural tube defect is myelomeningocele, in which the spinal… Expand
Fetal surgery for myelomeningocele and the incidence of shunt-dependent hydrocephalus.
- J. P. Bruner, N. Tulipan, +6 authors G. Reed
- Medicine
- JAMA
- 17 November 1999
CONTEXT
Intrauterine closure of exposed spinal cord tissue prevents secondary neurologic injury in animals with a surgically created spinal defect; however, whether in utero repair of… Expand
The Effect of Intrauterine Myelomeningocele Repair on the Incidence of Shunt-Dependent Hydrocephalus
- N. Tulipan, L. Sutton, J. P. Bruner, B. M. Cohen, M. Johnson, N. Adzick
- Medicine
- Pediatric Neurosurgery
- 2002
Background: Intrauterine myelomeningocele repair (IUMR) was first successfully performed in 1997. Preliminary reports suggest that this procedure reduces the incidence of shunt-dependent… Expand
Endoscopic coverage of fetal myelomeningocele in utero.
- J. P. Bruner, W. Richards, N. Tulipan, T. Arney
- Medicine
- American journal of obstetrics and gynecology
- 1999
OBJECTIVE
Our goal was to evaluate the safety and efficacy of minimally invasive surgery for the coverage of myelomeningocele in utero.
STUDY DESIGN
Women in the mid-second trimester of a pregnancy… Expand
Intrauterine repair of spina bifida: preoperative predictors of shunt-dependent hydrocephalus.
- J. P. Bruner, N. Tulipan, +4 authors M. Dabrowiak
- Medicine
- American journal of obstetrics and gynecology
- 1 December 2001
OBJECTIVE
The objective of this study was to determine which factors that are present at the time of intrauterine repair of spina bifida could predict the need for ventriculoperitoneal shunt for… Expand
Prenatal surgery for myelomeningocele and the need for cerebrospinal fluid shunt placement.
- N. Tulipan, J. Wellons, +10 authors N. S. Adzick
- Medicine
- Journal of neurosurgery. Pediatrics
- 15 September 2015
OBJECT
The Management of Myelomeningocele Study (MOMS) was a multicenter randomized trial comparing the safety and efficacy of prenatal and postnatal closure of myelomeningocele. The trial was… Expand
A randomized trial of prenatal versus postnatal repair of myelomeningocele.
BACKGROUND
Prenatal repair of myelomeningocele, the most common form of spina bifida, may result in better neurologic function than repair deferred until after delivery. We compared outcomes of in… Expand
In utero Repair of Myelomeningocele: A Comparison of Endoscopy and Hysterotomy
- J. P. Bruner, N. Tulipan, W. Richards, W. Walsh, F. Boehm, E. K. Vrabcak
- Medicine
- Fetal Diagnosis and Therapy
- 1 April 2000
Objective: To compare endoscopic coverage of myelomeningocele with a maternal split-thickness skin graft in utero to definitive neurosurgical closure through a hysterotomy. Methods: Four fetuses with… Expand
Intrauterine repair of spina bifida.
- J. P. Bruner, N. Tulipan
- Medicine
- Clinical obstetrics and gynecology
- 1 December 2005
Introduction In the current generation, 2 screening tests for neural tube defects are widely used. Combining the use of maternal serum alpha-fetoprotein screening with second-trimester ultrasound… Expand
A Randomized Trial of Prenatal Versus Postnatal Repair of Myelomeningocele
ABSTRACTMyelomeningocele is one of the most common birth defects, characterized by a defect in the bony spine and resultant extrusion of the spinal cord into a sac filled with cerebrospinal fluid. It… Expand