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Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice
Mammals respond to reduced food availability by becoming more wakeful and active, yet the central pathways regulating arousal and instinctual motor programs (such as food seeking) according toExpand
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Input of Orexin/Hypocretin Neurons Revealed by a Genetically Encoded Tracer in Mice
The finding of orexin/hypocretin deficiency in narcolepsy patients suggests that this hypothalamic neuropeptide plays a crucial role in regulating sleep/wakefulness states. However, very little isExpand
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Orexin/Hypocretin: A Neuropeptide at the Interface of Sleep, Energy Homeostasis, and Reward System
Recent studies have implicated the orexin system as a critical regulator of sleep/wake states as well as feeding behavior and reward processes. Orexin deficiency results in narcolepsy in humans,Expand
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Orexins activate histaminergic neurons via the orexin 2 receptor.
Orexins (orexin A and B) are recently identified neuropeptides implicated in the regulation of vigilance states and energy homeostasis. We have shown here the physiological significance ofExpand
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Input of Orexin/Hypocretin Neurons Revealed by a Genetically Encoded Tracer in Mice
The finding of orexin/hypocretin deficiency in narcolepsy patients suggests that this hypothalamic neuropeptide plays a crucial role in regulating sleep/wakefulness states. However, very little isExpand
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Regulation of orexin neurons by the monoaminergic and cholinergic systems.
Orexins are a pair of neuropeptides implicated in energy homeostasis and arousal. Here we characterize the electrophysiological properties of orexin neurons using slice preparations from transgenicExpand
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Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8
GPR7 and GPR8 are orphan G protein-coupled receptors that are highly similar to each other. These receptors are expressed predominantly in brain, suggesting roles in central nervous system function.Expand
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Orexin-induced food intake involves neuropeptide Y pathway
Orexins (orexin-A and -B) are recently identified neuropeptides, which are thought to be implicated in the regulation of feeding behavior. We used a NPY-Y1 receptor specific antagonist, BIBO3304, toExpand
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Serotonergic Regulation of the Orexin/Hypocretin Neurons through the 5-HT1A Receptor
Both orexin and serotonin (5-HT) have important roles in the regulation of sleep-wakefulness, as well as in feeding behavior. We examined the effects of 5-HT on orexin/hypocretin neurons, usingExpand
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Role of orexin in modulating arousal, feeding, and motivation
Orexin deficiency results in narcolepsy in humans, dogs, and rodents, suggesting that the orexin system is particularly important for maintenance of wakefulness. However, orexin neurons areExpand
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