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A mathematical model of Ca2+ dynamics in rat mesenteric smooth muscle cell: agonist and NO stimulation.
A mathematical model of calcium dynamics in vascular smooth muscle cell (SMC) was developed based on data mostly from rat mesenteric arterioles. The model focuses on (a) the plasma membraneExpand
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Erythrocyte consumption of nitric oxide in presence and absence of plasma-based hemoglobin.
Experimental measurements have suggested a consumption rate of nitric oxide (NO) by red blood cells (RBCs) that is orders of magnitude smaller than that of an equivalent concentration of freeExpand
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Endothelial Ca2+ wavelets and the induction of myoendothelial feedback.
When arteries constrict to agonists, the endothelium inversely responds, attenuating the initial vasomotor response. The basis of this feedback mechanism remains uncertain, although past studiesExpand
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A mathematical model of plasma membrane electrophysiology and calcium dynamics in vascular endothelial cells.
Vascular endothelial cells (ECs) modulate smooth muscle cell (SMC) contractility, assisting in vascular tone regulation. Cytosolic Ca(2+) concentration ([Ca(2+)](i)) and membrane potential (V(m))Expand
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A theoretical model of nitric oxide transport in arterioles: frequency- vs. amplitude-dependent control of cGMP formation.
Nitric oxide (NO) plays many important physiological roles, including the regulation of vascular smooth muscle tone. In response to hemodynamic or agonist stimuli, endothelial cells produce NO, whichExpand
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A mathematical model of vasoreactivity in rat mesenteric arterioles. II. Conducted vasoreactivity.
This study presents a multicellular computational model of a rat mesenteric arteriole to investigate the signal transduction mechanisms involved in the generation of conducted vasoreactivity. TheExpand
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A mathematical model of vasoreactivity in rat mesenteric arterioles: I. Myoendothelial communication
To study the effect of myoendothelial communication on vascular reactivity, we integrated detailed mathematical models of Ca2+ dynamics and membrane electrophysiology in arteriolar smooth muscleExpand
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Kinetic analysis of DAF-FM activation by NO: toward calibration of a NO-sensitive fluorescent dye.
Nitric oxide (NO) research in biomedicine has been hampered by the absence of a method that will allow quantitative measurement of NO in biological tissues with high sensitivity and selectivity, andExpand
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Model of nitric oxide diffusion in an arteriole: impact of hemoglobin-based blood substitutes.
Administration of hemoglobin-based oxygen carriers (HBOCs) frequently results in vasoconstriction that is primarily attributed to the scavenging of endothelium-derived nitric oxide (NO) by cell-freeExpand
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Nitric Oxide Bioavailability in the Microcirculation: Insights from Mathematical Models
  • N. Tsoukias
  • Biology, Medicine
  • Microcirculation
  • 1 November 2008
Over the last 30 years nitric oxide (NO) has emerged as a key signaling molecule involved in a number of physiological functions, including in the regulation of microcirculatory tone. DespiteExpand
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