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In vitro antiviral activity of dammar resin triterpenoids.
Nine triterpenes with antiviral activity against Herpes simplex virus types I and II in vitro were isolated from dammar resin. Each compound caused a significant reduction in viral cytopathic effect…
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Isolation and characterization of antibiotic X-14547A, a novel monocarboxylic acid ionophore produced by Streptomyces antibioticus NRRL 8167.
A novel carboxylic acid ionophore, antibiotic X-14547A, closely related to the polyether antibiotics has been isolated along with four other metabolites from fermented cultures of a new strain of…
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Isolation and characterization of antibiotic X-14931A, the naturally occurring 19-deoxyaglycone of dianemycin.
Sir: A number of polyether antibiotics containing two spiroketal functions in their molecular structure are known. They include dianemycin1, lenoremycin2 (A-I30A)3', and leuseramycin (TM-531A)'). In…
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Neoamphimedine: A New Pyridoacridine Topoisomerase II Inhibitor Which Catenates DNA
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Preparation, properties and biological activity of natural and semisynthetic urethanes of monensin.
TLDR
The most active derivatives are the phenylurethanes which are ten times more active in vitro against Gram-positive bacteria and unlike monensin are active against Candida albicans and Penicillium digitatum.
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Three new pseudodistomins, piperidine alkaloids from the ascidian Pseudodistoma megalarva.
TLDR
Bioassay-guided fractionation of the MeOH-CH2Cl2 extract of the Micronesian ascidian Pseudodistoma megalarva yielded three new piperidine alkaloids, pseudodistomins D-F and the previously reported pseudodismins B and C, which were established by interpretation of spectral data.
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The structure and absolute configuration of the 18-membered macrolide lactone antibiotic X-4357B (concanamycin A).
TLDR
The structure determination of this 18-membered macrolide antibiotic by X-ray analysis of its diacetate derivative is described and anisotropic thermal parameters were used for the non-hydrogen atoms and isotropic temperature factors were usedfor the hydrogen atoms.
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Isolation and characterization of a presumed biosynthetic precursor of camptothecin from extracts of Camptotheca acuminata
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Isolation and characterization of a novel polyether antibiotic of the pyrrolether class, antibiotic X-14885A.
TLDR
Antibiotic X-14885A is a polyether antibiotic belonging to the class of these natural acid ionophores known as pyrrolethers, and differs from the most well-known member of the class, A-23187, in two respects: the aromatic N-methylamino group present in the latter is replaced by a phenolic hydroxyl, and one of the four aliphatic methyls is replacing by a proton.
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Isolation and characterization of four polyether antibiotics, X-14889A, B, C, and D, closely related to lysocellin and the ferensimycins.
Streptomyces sp. X-14889 (NRRL 15517) has been found to produce a number of novel polyether antibiotics and an orange pigment. One of the antibiotics, X-14889B (3) was identified as ferensimycin A,…
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