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CDD: a Conserved Domain Database for the functional annotation of proteins
NCBI’s Conserved Domain Database (CDD) is a resource for the annotation of protein sequences with the location of conserved domain footprints, and functional sites inferred from these footprints. CDD
CDD: NCBI's conserved domain database
TLDR
NCBI's CDD, the Conserved Domain Database, enters its 15th year as a public resource for the annotation of proteins with the location of conserved domain footprints and aims at increasing coverage and providing finer-grained classifications of common protein domains.
CDD/SPARCLE: functional classification of proteins via subfamily domain architectures
NCBI's Conserved Domain Database (CDD) aims at annotating biomolecular sequences with the location of evolutionarily conserved protein domain footprints, and functional sites inferred from such
CDD: specific functional annotation with the Conserved Domain Database
TLDR
NCBI's Conserved Domain Database is a collection of multiple sequence alignments and derived database search models, which represent protein domains conserved in molecular evolution, and provides annotation of domain footprints and conserved functional sites on protein sequences.
CDD: a conserved domain database for interactive domain family analysis
TLDR
A novel helper application, CDTree, is presented, which enables users of the CDD resource to examine curated hierarchies and serve as a powerful tool in protein classification, as they allow users to analyze protein sequences in the context of domain family hierarchies.
CDD: conserved domains and protein three-dimensional structure
TLDR
To this date, the majority of protein 3D structures are represented by models tracked by CDD, and CDD curators are characterizing novel families that emerge from protein structure determination efforts.
InterPro in 2019: improving coverage, classification and access to protein sequence annotations
TLDR
Recent developments with InterPro (version 70.0) and its associated software are reported, including an 18% growth in the size of the database in terms on new InterPro entries, updates to content, the inclusion of an additional entry type, refined modelling of discontinuous domains, and the development of a new programmatic interface and website.
InterPro in 2017—beyond protein family and domain annotations
TLDR
Recent developments with InterPro are reported, including the addition of two new databases, and the functionality to include residue-level annotation and prediction of intrinsic disorder, which enrich the annotations provided by InterPro, increase the overall number of residues annotated and allow more specific functional inferences.
CDD/SPARCLE: the conserved domain database in 2020
As NLM's Conserved Domain Database (CDD) enters its 20th year of operations as a publicly available resource, CDD curation staff continues to develop hierarchical classifications of widely
RefSeq: an update on prokaryotic genome annotation and curation
Abstract The Reference Sequence (RefSeq) project at the National Center for Biotechnology Information (NCBI) provides annotation for over 95 000 prokaryotic genomes that meet standards for sequence
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