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Innate Immune Defense of the Sponge Suberites domuncula against Bacteria Involves a MyD88-dependent Signaling Pathway
Sponges (phylum Porifera) are the phylogenetically oldest metazoa; as filter feeders, they are abundantly exposed to marine microorganisms. Here we present data indicating that the demospongeExpand
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Antibacterial activity of the sponge Suberites domuncula and its primmorphs: potential basis for epibacterial chemical defense
The epibacterial chemical defense of the marine sponge Suberites domuncula was explored by screening sponge extract, sponge primmorph (3-D aggregates containing proliferating cells) extract andExpand
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Antiangiogenic, Antimicrobial, and Cytotoxic Potential of Sponge-Associated Bacteria
The bacteria associated with marine invertebrates are a rich source of bioactive metabolites. In the present study bacteria associated with the sponge Suberites domuncula and its primmorphsExpand
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Molecular/chemical ecology in sponges: evidence for an adaptive antibacterial response in Suberites domuncula
Sponges (Porifera) represent the evolutionary oldest metazoan phylum still extant today. They have developed a complex Bauplan, based on the existence of structural and regulatory molecules; many ofExpand
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Marine natural products in drug discovery
Marine organisms comprise approximately a half of the total biodiversity, thus offering a vast source to discover useful therapeutics. In recent years, a significant number of novel metabolites withExpand
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Emergence and Disappearance of an Immune Molecule, an Antimicrobial Lectin, in Basal Metazoa
Sponges (phylum Porifera) represent the evolutionarily oldest metazoans that comprise already a complex immune system and are related to the crown taxa of the protostomians and the deuterostomians.Expand
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Innate immune defense of the sponge Suberites domuncula against gram-positive bacteria: induction of lysozyme and AdaPTin
Sponges are filter feeders that are exposed to large amounts of bacteria present in their surrounding aqueous milieu. The characteristic cell wall component of gram-positive bacteria, peptidoglycanExpand
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Oxygen-Controlled Bacterial Growth in the Sponge Suberites domuncula: toward a Molecular Understanding of the Symbiotic Relationships between Sponge and Bacteria
ABSTRACT Sponges (phylum Porifera), known to be the richest producers among the metazoans of bioactive secondary metabolites, are assumed to live in a symbiotic relationship with microorganisms,Expand
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Marine biotechnology: An overview
Marine biotechnology is the creation of products and processes from marine organisms through the application of the techniques of biotechnology, molecular and cellular biology, and bioinformatics.Expand
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Biotechnological potential of marine sponges
Marine sponges (Porifera) have attracted significant attention from various scientific disciplines. Remarkable traces, left by sponges in the fossil records have been studied by paleontologists andExpand
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