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- Publications
- Influence
Innate Immune Defense of the Sponge Suberites domuncula against Bacteria Involves a MyD88-dependent Signaling Pathway
- M. Wiens, M. Korzhev, +7 authors W. Müller
- Biology, Medicine
- Journal of Biological Chemistry
- 29 July 2005
Sponges (phylum Porifera) are the phylogenetically oldest metazoa; as filter feeders, they are abundantly exposed to marine microorganisms. Here we present data indicating that the demosponge… Expand
Antibacterial activity of the sponge Suberites domuncula and its primmorphs: potential basis for epibacterial chemical defense
- N. Thakur, U. Hentschel, A. Krasko, Christian T. Pabel, A. C. Anil, W. Müller
- Biology
- 13 February 2003
The epibacterial chemical defense of the marine sponge Suberites domuncula was explored by screening sponge extract, sponge primmorph (3-D aggregates containing proliferating cells) extract and… Expand
Antiangiogenic, Antimicrobial, and Cytotoxic Potential of Sponge-Associated Bacteria
- A. Thakur, N. Thakur, M. Indap, Reena Pandit, V. V. Datar, W. Müller
- Biology, Medicine
- Marine Biotechnology
- 24 March 2005
The bacteria associated with marine invertebrates are a rich source of bioactive metabolites. In the present study bacteria associated with the sponge Suberites domuncula and its primmorphs… Expand
Molecular/chemical ecology in sponges: evidence for an adaptive antibacterial response in Suberites domuncula
- W. E. Müller, M. Klemt, +5 authors E. Fattorusso
- Biology
- 2004
Sponges (Porifera) represent the evolutionary oldest metazoan phylum still extant today. They have developed a complex Bauplan, based on the existence of structural and regulatory molecules; many of… Expand
Marine natural products in drug discovery
- N. Thakur, A. Thakur, W. Müller, D. Ruparel
- Biology
- 1 December 2005
Marine organisms comprise approximately a half of the total biodiversity, thus offering a vast source to discover useful therapeutics. In recent years, a significant number of novel metabolites with… Expand
- 30
- 3
- PDF
Emergence and Disappearance of an Immune Molecule, an Antimicrobial Lectin, in Basal Metazoa
- H. Schröder, H. Ushijima, +5 authors W. Müller
- Medicine, Biology
- Journal of Biological Chemistry
- 29 August 2003
Sponges (phylum Porifera) represent the evolutionarily oldest metazoans that comprise already a complex immune system and are related to the crown taxa of the protostomians and the deuterostomians.… Expand
Innate immune defense of the sponge Suberites domuncula against gram-positive bacteria: induction of lysozyme and AdaPTin
- N. Thakur, S. Perović-Ottstadt, +4 authors W. Müller
- Biology
- 2005
Sponges are filter feeders that are exposed to large amounts of bacteria present in their surrounding aqueous milieu. The characteristic cell wall component of gram-positive bacteria, peptidoglycan… Expand
Oxygen-Controlled Bacterial Growth in the Sponge Suberites domuncula: toward a Molecular Understanding of the Symbiotic Relationships between Sponge and Bacteria
- W. Mueller, V. A. Grebenjuk, +5 authors H. J. Breter
- Biology, Medicine
- Applied and Environmental Microbiology
- 1 April 2004
ABSTRACT Sponges (phylum Porifera), known to be the richest producers among the metazoans of bioactive secondary metabolites, are assumed to live in a symbiotic relationship with microorganisms,… Expand
Marine biotechnology: An overview
Marine biotechnology is the creation of products and processes from marine organisms through the application of the techniques of biotechnology, molecular and cellular biology, and bioinformatics.… Expand
- 16
- 2
- PDF
Biotechnological potential of marine sponges
- N. Thakur, W. Mueller
- Biology
- 2004
Marine sponges (Porifera) have attracted significant attention from various scientific disciplines. Remarkable traces, left by sponges in the fossil records have been studied by paleontologists and… Expand
- 133
- 1
- PDF