N. Thakor

Publications43
h-index16
Citations1,044
Highly Influential Citations56
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Engineering neuronal growth cones to promote axon regeneration over inhibitory molecules
  • E. Hur, I. Yang, +8 authors F. Zhou
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 7 March 2011
Neurons in the central nervous system (CNS) fail to regenerate axons after injuries due to the diminished intrinsic axon growth capacity of mature neurons and the hostile extrinsic environment… Expand
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Valve-based microfluidic compression platform: single axon injury and regrowth.
We describe a novel valve-based microfluidic axon injury micro-compression (AIM) platform that enables focal and graded compression of micron-scale segments of single central nervous system (CNS)… Expand
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Toll/Interleukin-1 Receptor Domain-Containing Adapter Inducing Interferon-β Mediates Microglial Phagocytosis of Degenerating Axons
Following CNS injury, microglial phagocytosis of damaged endogenous tissue is thought to play an important role in recovery and regeneration. Previous work has focused on delineating mechanisms of… Expand
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Compartmentalized microfluidic culture platform to study mechanism of paclitaxel-induced axonal degeneration
Chemotherapy induced peripheral neuropathy is a common and dose-limiting side effect of anticancer drugs. Studies aimed at understanding the underlying mechanism of neurotoxicity of chemotherapeutic… Expand
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Time-Dependent Entropy Estimation of EEG Rhythm Changes Following Brain Ischemia
AbstractOur approach is motivated by the need to generate a rigorous measure of the degree of disorder (or complexity) of the EEG signal in brain injury. Entropy is a method to quantify the… Expand
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Removal of ECG interference from the EEG recordings in small animals using independent component analysis
In experiments involving small animals, the electroencephalogram (EEG) recorded during severe injury and accompanying resuscitation exhibit the strong presence of electrocardiogram (ECG). For… Expand
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EEG Cortical Connectivity Analysis of Working Memory Reveals Topological Reorganization in Theta and Alpha Bands
Numerous studies have revealed various working memory (WM)-related brain activities that originate from various cortical regions and oscillate at different frequencies. However, multi-frequency band… Expand
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Conjugated polymer and drug co-encapsulated nanoparticles for chemo- and photo-thermal combination therapy with two-photon regulated fast drug release.
The spatial-temporal synchronization of photothermal therapy and chemotherapy is highly desirable for an efficient cancer treatment with synergistic effect. Herein, we developed a chemotherapeutic… Expand
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Neuronal activity promotes myelination via a cAMP pathway
Neuronal activity promotes myelination in vivo and in vitro. However, the molecular events that mediate activity‐dependent myelination are not completely understood. Seven, daily 1 h sessions of… Expand
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Axon Myelination and Electrical Stimulation in a Microfluidic, Compartmentalized Cell Culture Platform
Axon demyelination contributes to the loss of sensory and motor function following injury or disease in the central nervous system. Numerous reports have demonstrated that myelination can be achieved… Expand
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