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Role of interleukin‐1β in postoperative cognitive dysfunction
Although postoperative cognitive dysfunction (POCD) often complicates recovery from major surgery, the pathogenic mechanisms remain unknown. We explored whether systemic inflammation, in response toExpand
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Tumor necrosis factor-α triggers a cytokine cascade yielding postoperative cognitive decline
Cognitive decline following surgery in older individuals is a major clinical problem of uncertain mechanism; a similar cognitive decline also follows severe infection, chemotherapy, or trauma and isExpand
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Resolving postoperative neuroinflammation and cognitive decline
Cognitive decline accompanies acute illness and surgery, especially in the elderly. Surgery engages the innate immune system that launches a systemic inflammatory response that, if unchecked, canExpand
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The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction
IntroductionThe impact of pro-inflammatory cytokines on neuroinflammation and cognitive function after lipopolysaccharide (LPS) challenge remains elusive. Herein we provide evidence that there is aExpand
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Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice
IntroductionAcute kidney injury following surgery incurs significant mortality with no proven preventative therapy. We investigated whether the α2 adrenoceptor agonist dexmedetomidine (Dex) providesExpand
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Perioperative cognitive decline in the aging population.
Elderly patients who have an acute illness or who undergo surgery often experience cognitive decline. The pathophysiologic mechanisms that cause neurodegeneration resulting in cognitive decline,Expand
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Surgery Upregulates High Mobility Group Box‐1 and Disrupts the Blood–Brain Barrier causing Cognitive Dysfunction in Aged Rats
Postoperative cognitive dysfunction (POCD) is a growing and largely underestimated problem without defined etiology. Herein, we sought to determine the relationship between cognitive decline,Expand
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Neuroinflammation and Central Sensitization in Chronic and Widespread Pain.
Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic plasticity, and increased neuronal responsiveness in central pain pathways after painful insults. AccumulatingExpand
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Perioperative cerebrospinal fluid and plasma inflammatory markers after orthopedic surgery
BackgroundPostoperative delirium is prevalent in older patients and associated with worse outcomes. Recent data in animal studies demonstrate increases in inflammatory markers in plasma andExpand
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Prolonged Neuroinflammation after Lipopolysaccharide Exposure in Aged Rats
Inflammation is a hallmark of several disease states ranging from neurodegeneration to sepsis but is also implicated in physiological processes like ageing. Non-resolving inflammation and prolongedExpand
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