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Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites
Helminth parasitic infections are a major global health and social burden. The host defence against helminths such as Nippostrongylus brasiliensis is orchestrated by type 2 cell-mediated immunity.Expand
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Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells
T cell development and selection are coordinated in the thymus by a specialized niche of diverse stromal populations1–3. Although much progress has been made over the years in identifying theExpand
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Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
Altering the availability of nutrients shapes T cell differentiation and the immune response. Feeding immune responses When a naïve CD4+ T cell is activated by antigen, cytokines determine whether itExpand
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Defective expression of p56lck in an infant with severe combined immunodeficiency.
Severe combined immune deficiency (SCID) is a heterogeneous disorder characterized by profound defects in cellular and humoral immunity. We report here an infant with clinical and laboratory featuresExpand
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Glut1-mediated glucose transport regulates HIV infection
Cell cycle entry is commonly considered to positively regulate HIV-1 infection of CD4 T cells, raising the question as to how quiescent lymphocytes, representing a large portion of the viralExpand
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In vivo correction of ZAP-70 immunodeficiency by intrathymic gene transfer.
SCID patients have been successfully treated by administration of ex vivo gene-corrected stem cells. However, despite its proven efficacy, such treatment carries specific risks and difficulties. WeExpand
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Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors.
Current therapeutic strategies for sickle cell anemia are aimed at reactivating fetal hemoglobin. Pomalidomide, a third-generation immunomodulatory drug, was proposed to induce fetal hemoglobinExpand
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Development of adoptive cell therapy for cancer: a clinical perspective.
Adoptive cellular therapy provides the promise of a potentially powerful general treatment for cancer. Although this is a complex and challenging field, there have been major advances in basic andExpand
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gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes.
The capacity of the HIV-1 envelope glycoprotein gp120 to induce intracellular signals is thought to contribute to HIV-1 pathogenesis. Here, we report that gp120 binding resulted in activation of theExpand
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Resveratrol stimulates the metabolic reprogramming of human CD4+ T cells to enhance effector function
Resveratrol alters human T cell responsiveness to antigens, coupling a replication stress response to metabolic reprogramming. Resveratrol and lymphocyte responses Resveratrol is a polyphenolic plantExpand
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