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E2-p7 Region of the Bovine Viral Diarrhea Virus Polyprotein: Processing and Functional Studies
ABSTRACT The genes encoding pestivirus E2 and NS2-3 are separated by a sequence that encodes a small hydrophobic polypeptide with an apparent molecular mass of 6 to 7 kDa (p7). It has been shown thatExpand
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Characterization of an Autonomous Subgenomic Pestivirus RNA Replicon
ABSTRACT As an initial approach to define the requirements for the replication of bovine viral diarrhea virus (BVDV), a member of theFlaviviridae family with a positive-strand RNA genome, full-lengthExpand
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The Molecular Biology of Pestiviruses.
Pestiviruses are among the economically most important pathogens of livestock. The biology of these viruses is characterized by unique and interesting features that are both crucial for their successExpand
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Processing in the pestivirus E2-NS2 region: identification of proteins p7 and E2p7.
The pestivirus genome encodes a single polyprotein which is subject to co- and posttranslational processing by cellular and viral proteases. The map positions of all virus-encoded proteins are knownExpand
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A Cellular J-Domain Protein Modulates Polyprotein Processing and Cytopathogenicity of a Pestivirus
ABSTRACT Pestiviruses are positive-strand RNA viruses closely related to human hepatitis C virus. Gene expression of these viruses occurs via translation of a polyprotein, which is further processedExpand
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Dissection of a viral autoprotease elucidates a function of a cellular chaperone in proteolysis
Replication of positive-strand RNA viruses involves translation of polyproteins which are proteolytically processed into functional peptides. These maturation steps often involve virus-encodedExpand
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Serine protease of pestiviruses: determination of cleavage sites.
The single-stranded genomic RNA of pestiviruses is of positive polarity and encompasses one large open reading frame of about 4,000 codons. The resulting polyprotein is processed co- andExpand
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Molecular characterization of border disease virus, a pestivirus from sheep.
Three serologically different pestivirus strains isolated from sheep were selected for molecular analysis. cDNA and deduced amino acid sequences of the genomic regions encoding glycoproteins E1 andExpand
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Establishment and Characterization of Cytopathogenic and Noncytopathogenic Pestivirus Replicons
ABSTRACT Defective interfering particles (DIs) of bovine viral diarrhea virus (BVDV) have been identified and shown to be cytopathogenic (cp) in the presence of noncytopathogenic (noncp) helperExpand
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