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TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.
TGF-beta-activated kinase 1 (TAK1), a member of the MAPKKK family, is thought to be a key modulator of the inducible transcription factors NF-kappaB and AP-1 and, therefore, plays a crucial role in… Expand
Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction
Induction of the interferon (IFN)-alpha/beta gene transcription in virus-infected cells is an event central to innate immunity. Mice lacking the transcription factor IRF-3 are more vulnerable to… Expand
Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
Nrf2 (NF-E2-related factor-2) transcription factor regulates oxidative/xenobiotic stress response and also represses inflammation. However, the mechanisms how Nrf2 alleviates inflammation are still… Expand
Mechanism of p38 MAP kinase activation in vivo.
The p38 mitogen-activated protein kinase (MAPK) is activated in vitro by three different protein kinases: MKK3, MKK4, and MKK6. To examine the relative roles of these protein kinases in the mechanism… Expand
Acclimation to sudden increase in light favoring an invasive over native trees in subtropical islands, Japan
Abstract Bischofia javanica Blume, an exotic tree, dominates many forest areas of the Bonin Islands in the western Pacific of Japan. The aim of this study was to test the hypothesis that the success… Expand
Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1
The transcriptional activator interferon regulatory factor 1 (IRF-1) and its antagonistic repressor IRF-2 are regulators of the interferon (IFN) system and of cell growth. Here we report that… Expand
Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase
Abdominal aortic aneurysm (AAA) is a common disease among elderly people that, when surgical treatment is inapplicable, results in progressive expansion and rupture of the aorta with high mortality.… Expand
Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer.
- T. Nakagawa, Hiroyuki Endo, +7 authors K. Satoh
- Biology, Medicine
- Biochemical and biophysical research…
- 28 June 2013
HOTAIR is one of long non-coding RNAs and its expression correlates with the prognosis and metastasis in various cancers. We showed that HOTAIR expression has an important role in the development of… Expand
Clathrin-Dependent Entry of Severe Acute Respiratory Syndrome Coronavirus into Target Cells Expressing ACE2 with the Cytoplasmic Tail Deleted
ABSTRACT The penetration of various viruses into host cells is accomplished by hijacking the host endocytosis machinery. In the case of severe acute respiratory syndrome coronavirus (SARS-CoV)… Expand
Rheumatoid arthritis-related lung diseases: CT findings.
PURPOSE To evaluate computed tomographic (CT) findings of rheumatoid arthritis-related lung disease and categorize findings according to pathologic features. MATERIALS AND METHODS CT scans obtained… Expand