N. Tamaki

Publications84
h-index20
Citations1,326
Highly Influential Citations35
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A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution.
Purification, characterization and inhibition of dihydropyrimidinase from rat liver.
TLDR
The results suggest that dihydropyrimidinase has no stereo specificities for 5-substituents of H2Ura, and the addition of N- carbamoyl-beta-alanine or N-carbamoyL- beta-amino-isobutyric acid showed hyperbolic mixed-type inhibition, when BrH2URA was used as the substrate.
Inhibitory effects of Zn2+ on muscle glycolysis and their reversal by histidine.
TLDR
These studies indicate that in rat skeletal muscle the inhibitory effect of Zn2+ on lactate production might result from the inhibition of phosphofructokinase and that histidine could remove the effect.
Dihydropyrimidinase deficiency: structural organization, chromosomal localization, and mutation analysis of the human dihydropyrimidinase gene.
TLDR
Mutation analysis of genomic DNA in one symptomatic and five asymptomatic individuals presenting with dihydropyrimidinuria showed that all mutations reduced enzyme activity significantly, indicating that these are crucial DHP deficiency-causing mutations.
Purification, characterization and inhibition of D-3-aminoisobutyrate aminotransferase from the rat liver.
TLDR
6-Azauracil and 6-azathymine were found to be potent inhibitors of purified rat liver D-3-aminoisobutyrate-pyruvate aminotransferase, which catalyzed the transamination of omega-amino acids and pyruvic acid, glyoxylic acid and oxaloacetic acid were favorable amino acceptors.
Purification and properties of aldehyde dehydrogenase from Saccharomyces cerevisiae.
TLDR
A procedure for the purification of aldehyde dehydrogenase from bakers' yeast (Saccharomyces cerevisiae) is reported and the substrate specificity, the relative maximal velocity, the michaelis constants, the pH optimum, the stability and the activation energy of the enzyme are reported.
Dihydropyrimidinase deficiency and severe 5-fluorouracil toxicity.
TLDR
It is demonstrated for the first time that in one patient the severe toxicity, after a treatment with 5FU, was attributable to a partial deficiency of DHP.
The utilization of carnosine in rats fed on a histidine-free diet and its effect on the levels of tissue histidine and carnosine.
TLDR
Rats fed on the histidine-free diet lost weight rapidly for a few days, then remained at a relatively constant weight for 2 weeks at least, but rats fed on a 0.90% carnosine diet, which contains histidine equimolar to that in a 20% casein diet, increased their weight at the same rate as rats feeding on a20% amino acid diet simulated with casein.
Biosynthesis and degradation of carnosine and turnover rate of its constituent amino acids in rats.
TLDR
The biosynthesis and destruction of anserine and carnosine in the rat were investigated in vivo using radioactive β-alanine, histidine and methylhistidine and radioactivity arising from 3H-Nπ-methylhistidine was detected in gastrocnemius muscle of the rat pretreated with β-Alanine.
The mature size of rat 4-aminobutyrate aminotransferase is different in liver and brain.
TLDR
The amino acid sequence predicted from a rat liver cDNA library indicated that the precursor of beta-AlaAT I consists of a mature enzyme of 466 amino acid residues and a 34-amino acid terminal segment, with amino acids attributed to the leader peptide.
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