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A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution.
We have isolated cDNA clones encoding dihydropyrimidinase (DHPase) from human liver and its three homologues from human fetal brain. The deduced amino acid (aa) sequence of human DHPase showed 90%Expand
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Purification, characterization and inhibition of dihydropyrimidinase from rat liver.
Dihydropyrimidinase (DHPase) was purified 564-fold over the initial rat liver extract, using heat, ammonium sulfate fractionation, DEAE-Sepharose CL-6B, carboxymethyl-Sepharose CL-6B, hydroxyapatiteExpand
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Dihydropyrimidinase deficiency: structural organization, chromosomal localization, and mutation analysis of the human dihydropyrimidinase gene.
Dihydropyrimidinase (DHP) deficiency (MIM 222748) is characterized by dihydropyrimidinuria and is associated with a variable clinical phenotype. This disease might be associated with a risk ofExpand
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Purification, characterization and inhibition of D-3-aminoisobutyrate aminotransferase from the rat liver.
D-3-Aminoisobutyrate-pyruvate aminotransferase was purified 2000-fold from rat liver extract using heat treatment, ammonium sulfate fractionation, carboxylmethyl-Sepharose CL-6B, DEAE-SepharoseExpand
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Inhibitory effects of Zn2+ on muscle glycolysis and their reversal by histidine.
Of a number of divalent cations investigated, Zn2+ strongly inhibited lactate production from glucose 6-phosphate in rat muscle cytosol fraction. The I50 value for lactate production influenced byExpand
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Purification and properties of aldehyde dehydrogenase from Saccharomyces cerevisiae.
A procedure for the purification of aldehyde dehydrogenase from bakers' yeast (Saccharomyces cerevisiae) is reported. Treatment with acid, heat and organic solvents was avoided and chromatographicExpand
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Dihydropyrimidinase deficiency and severe 5-fluorouracil toxicity.
Dihydropyrimidinase (DHP) is the second enzyme in the catabolism of 5-fluorouracil (5FU), and it has been suggested that patients with a deficiency of this enzyme are at risk from developing severeExpand
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The utilization of carnosine in rats fed on a histidine-free diet and its effect on the levels of tissue histidine and carnosine.
Carnosine can support the growth of rats fed on a histidine-free diet. Rats fed on the histidine-free diet lost weight rapidly for a few days, then remained at a relatively constant weight for 2Expand
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The mature size of rat 4-aminobutyrate aminotransferase is different in liver and brain.
The amino acid sequence predicted from a rat liver cDNA library indicated that the precursor of beta-AlaAT I (4-aminobutyrate aminotransferase, beta-alanine-oxoglutarate aminotransferase) consists ofExpand
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Activation of rabbit muscle fructose 1,6-bisphosphatase by histidine and carnosine.
Histidine and its derivatives increased rabbit muscle fructose 1,6-bisphosphatase activity at neutral pH with positive cooperativity. In the presence of histidine and carnosine the optimum pH shiftedExpand
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