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Purification, characterization and inhibition of dihydropyrimidinase from rat liver.
Dihydropyrimidinase (DHPase) was purified 564-fold over the initial rat liver extract, using heat, ammonium sulfate fractionation, DEAE-Sepharose CL-6B, carboxymethyl-Sepharose CL-6B, hydroxyapatiteExpand
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Dihydropyrimidinase deficiency: structural organization, chromosomal localization, and mutation analysis of the human dihydropyrimidinase gene.
Dihydropyrimidinase (DHP) deficiency (MIM 222748) is characterized by dihydropyrimidinuria and is associated with a variable clinical phenotype. This disease might be associated with a risk ofExpand
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Purification, characterization and inhibition of D-3-aminoisobutyrate aminotransferase from the rat liver.
D-3-Aminoisobutyrate-pyruvate aminotransferase was purified 2000-fold from rat liver extract using heat treatment, ammonium sulfate fractionation, carboxylmethyl-Sepharose CL-6B, DEAE-SepharoseExpand
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Inhibitory effects of Zn2+ on muscle glycolysis and their reversal by histidine.
Of a number of divalent cations investigated, Zn2+ strongly inhibited lactate production from glucose 6-phosphate in rat muscle cytosol fraction. The I50 value for lactate production influenced byExpand
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Dihydropyrimidinase deficiency and severe 5-fluorouracil toxicity.
Dihydropyrimidinase (DHP) is the second enzyme in the catabolism of 5-fluorouracil (5FU), and it has been suggested that patients with a deficiency of this enzyme are at risk from developing severeExpand
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Purification and properties of aldehyde dehydrogenase from Saccharomyces cerevisiae.
A procedure for the purification of aldehyde dehydrogenase from bakers' yeast (Saccharomyces cerevisiae) is reported. Treatment with acid, heat and organic solvents was avoided and chromatographicExpand
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The utilization of carnosine in rats fed on a histidine-free diet and its effect on the levels of tissue histidine and carnosine.
Carnosine can support the growth of rats fed on a histidine-free diet. Rats fed on the histidine-free diet lost weight rapidly for a few days, then remained at a relatively constant weight for 2Expand
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The mature size of rat 4-aminobutyrate aminotransferase is different in liver and brain.
The amino acid sequence predicted from a rat liver cDNA library indicated that the precursor of beta-AlaAT I (4-aminobutyrate aminotransferase, beta-alanine-oxoglutarate aminotransferase) consists ofExpand
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Activation of rabbit muscle fructose 1,6-bisphosphatase by histidine and carnosine.
Histidine and its derivatives increased rabbit muscle fructose 1,6-bisphosphatase activity at neutral pH with positive cooperativity. In the presence of histidine and carnosine the optimum pH shiftedExpand
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Submitochondrial localization of rat liver beta-alanine-oxoglutarate aminotransferase.
beta-Alanine-oxoglutarate aminotransferase from rat liver was mainly distributed in the mitochondrial fraction, while beta-ureidopropionase, the last one of uracil-metabolizing enzymes toExpand
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