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Direct, trace level detection of explosives on ambient surfaces by desorption electrospray ionization mass spectrometry.
- Z. Takáts, Ismael Cotte-Rodríguez, N. Talaty, Huanwen Chen, R. Cooks
- ChemistryChemical communications
- 13 April 2005
Desorption electrospray ionization (DESI) mass spectrometry is used to detect trace amounts of explosives present on a variety of ambient surfaces in 5-second analysis times without any sample…
Desorption electrospray ionization mass spectrometry for high-throughput analysis of pharmaceutical samples in the ambient environment.
Positive and negative ion DESI are used to characterize the active ingredients in pharmaceutical samples formulated as tablets, ointments, and liquids, and carryover effects are minimized in high-throughput on-line analysis of pharmaceutical samples.
Detection of explosives on skin using ambient ionization mass spectrometry.
- D. Justes, N. Talaty, Ismael Cotte-Rodríguez, R. Cooks
- Chemistry, EngineeringChemical communications
- 22 May 2007
Single nanogram amounts of the explosives TNT, RDX, HMX, PETN and their mixtures were detected and identified in a few seconds on the surface of human skin without any sample preparation by…
Desorption electrospray ionization with a portable mass spectrometer: in situ analysis of ambient surfaces.
Desorption electrospray ionization (DESI) is implemented on a portable mass spectrometer and used to demonstrate in situ detection of active ingredients in pharmaceutical preparations, alkaloids in…
Desorption electrospray ionization of explosives on surfaces: sensitivity and selectivity enhancement by reactive desorption electrospray ionization.
- Ismael Cotte-Rodríguez, Z. Takáts, N. Talaty, Huanwen Chen, R. Cooks
- ChemistryAnalytical chemistry
- 29 September 2005
Desorption electrospray ionization (DESI), an ambient mass spectrometry technique, is used for trace detection of the explosives trinitrohexahydro-1,3,5-triazine (RDX),…
Fabric analysis by ambient mass spectrometry for explosives and drugs.
- N. Talaty, Christopher C Mulligan, D. Justes, A. Jackson, R. Noll, R. Cooks
- ChemistryThe Analyst
- 20 October 2008
Desorption electrospray ionization was used to examine cotton transfer swabs used for travel security sample collection in the screening process and high throughput quantitative analysis of fabric surfaces for targeted analytes is reported.
Principal component analysis of urine metabolites detected by NMR and DESI–MS in patients with inborn errors of metabolism
The combined approach discussed here may prove useful in the rapid screening of biological fluids from sick patients and may help to improve the understanding of these rare diseases.
Rapid analysis of metabolites and drugs of abuse from urine samples by desorption electrospray ionization-mass spectrometry.
- T. Kauppila, N. Talaty, T. Kuuranne, T. Kotiaho, R. Kostiainen, R. Cooks
- ChemistryThe Analyst
- 20 August 2007
Urine samples obtained from drug abusers were screened for drugs of abuse and their metabolites using DESI-MS and the results obtained were compared to results obtained from GC-MS experiments, indicating that the sensitivity of DESI was more than adequate for this study.
A quantitation method for mass spectrometry imaging.
- Stormy L Koeniger, N. Talaty, S. Spanton
- Chemistry, BiologyRapid communications in mass spectrometry : RCM
- 28 February 2011
A new quantitation method for mass spectrometry imaging (MSI) with matrix-assisted laser desorption/ionization (MALDI) has been developed and its importance in pharmaceutical analysis, and the considerations necessary when implementing it are presented.
New surfaces for desorption electrospray ionization mass spectrometry: porous silicon and ultra-thin layer chromatography plates.
- T. Kauppila, N. Talaty, P. Salo, T. Kotiaho, R. Kostiainen, R. Cooks
- Materials ScienceRapid communications in mass spectrometry : RCM
- 30 July 2006
The performance of nanoporous silicon (pSi) and ultra-thin layer chromatography (UTLC) plates as surfaces for desorption electrospray ionization (DESI) was compared with that of polymethyl…