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Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.
We analyzed the complete mitochondrial DNA (mtDNA) sequences of three humans (African, European, and Japanese), three African apes (common and pygmy chimpanzees, and gorilla), and one orangutan in anExpand
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Allelic genealogy under overdominant and frequency-dependent selection and polymorphism of major histocompatibility complex loci.
To explain the long-term persistence of polymorphic alleles (trans-specific polymorphism) at the major histocompatibility complex (MHC) loci in rodents and primates, a computer simulation study wasExpand
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A simple genealogical structure of strongly balanced allelic lines and trans-species evolution of polymorphism.
  • N. Takahata
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 April 1990
Different alleles undergoing strong symmetric balancing selection show a simple genealogical structure (allelic genealogy), similar to the gene genealogy described by the coalescence process for aExpand
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Divergence time and population size in the lineage leading to modern humans.
We have developed maximum likelihood (ML) methods for comparisons of nucleotide sequences from unlinked genomic regions. In the case of a single species, the ML method primarily estimates theExpand
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The origin and age of haplochromine fishes in Lake Victoria, East Africa
According to a widely held view, the more than 300 species of haplochromine cichlid fishes in Lake Victoria (LV), East Africa, originated from a single founder species in less than 12 000 years. ThisExpand
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Intensity of natural selection at the major histocompatibility complex loci.
Long persistence of allelic lineages, prevalence of nonsynonymous over synonymous substitutions in the peptide-binding region (PBR), and deviation from neutrality of the expected gene identityExpand
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Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution
Humans are genetically deficient in the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) because of an Alu-mediated inactivating mutation of the gene encoding the enzymeExpand
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Gene genealogy in three related populations: consistency probability between gene and population trees.
A genealogical relationship among genes at a locus (gene tree) sampled from three related populations was examined with special reference to population relatedness (population tree). AExpand
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Gene genealogy and variance of interpopulational nucleotide differences.
A mathematical theory is developed for computing the probability that m genes sampled from one population (species) and n genes sampled from another are derived from l genes that existed at the timeExpand
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Allelic genealogy and human evolution.
  • N. Takahata
  • Biology, Medicine
  • Molecular biology and evolution
  • 1993
Genetic variation at most loci examined in human populations indicates that the (effective) population size has been approximately 10(4) for the past 1 Myr and that individuals have been geneticallyExpand
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