N. Takahashi

Publications115
h-index22
Citations1,933
Highly Influential Citations31
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Activation of p38 MAP kinase and JNK but not ERK is required for erythropoietin-induced erythroid differentiation.
TLDR
Results indicate that activation of p38 and JNKs but not of ERKs is required for Epo-induced erythroid differentiation of SKT6 cells, whereas all of these kinases are involved in EpO-induced mitogenesis of FD-EPO cells.
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Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
N-Phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas were found to be a novel class of potent inhibitors for the vascular endothelial growth factor receptor 2 (VEGFR-2) tyrosine kinase through synthetic…
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Retinoic acid metabolism and inhibition of cell proliferation: an unexpected liaison.
TLDR
It is concluded that a relationship exists between RA inhibition of cell growth and intracellular RA metabolism and these data may help design useful strategies in cancer therapy by retinoids and dispel the notion that RA itself is responsible for the inhibition of Cell growth.
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Antioxidative collagen-derived peptides in human-placenta extract.
TLDR
Results suggest that peptides produced from collagen are also antioxidative components of PLx, which appear to be derived from collagen.
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L-tryptophan as an antioxidant in human placenta extract.
TLDR
The results suggest that L-Trp is a main antioxidant of HPE of which the effect is based on the suppression of lipid peroxidation in the oxidative stress status.
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A close relationship between type 1 diabetes and vitamin A‐deficiency and matrix metalloproteinase and hyaluronidase activities in skin tissues
TLDR
Results indicate a close relationship between type 1 diabetes and vitamin A‐deficiency on MMP and HAase in skin tissues, suggesting that type 1 diabetic rats could be vitamin A-deficient.
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Retinoic acid acylation (retinoylation) of a nuclear protein in the human acute myeloid leukemia cell line HL60.
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Formation of retinoyl-CoA in rat tissues.
TLDR
The results indicate that ATP-dependent generation of retinoyl-CoA occurs in rat tissues and may play a significant physiological role in RA actions mediated byretinoylation.
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Expression of acetoacetyl-CoA synthetase, a novel cytosolic ketone body-utilizing enzyme, in human brain.
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Different localization in rat brain of the novel cytosolic ketone body-utilizing enzyme, acetoacetyl-CoA synthetase, as compared to succinyl-CoA:3-oxoacid CoA-transferase.
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