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Mechanisms underlying the long-term behavioral effects of traumatic experience in rats: The role of serotonin/noradrenaline balance and NMDA receptors
Traumatic stressors induce long-lasting changes in behavior. It is believed that all three glutamatergic, serotonergic and noradrenergic neurotransmission play a role in the development of suchExpand
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Pharmacological evaluation of the stress-induced social avoidance model of anxiety
We have shown earlier that mild electric shocks induce a lasting social avoidance in male rats. Here we investigated whether shock-induced social avoidance can be developed into a laboratory model ofExpand
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Effects of single and simultaneous lesions of serotonergic and noradrenergic pathways on open-space and bright-space anxiety-like behavior in two animal models
The objective of the present study is to investigate the effects of single and simultaneous lesions of the noradrenergic and serotonergic pathways (NA-X, 5-HT-X and XX, respectively) byExpand
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AMPA receptor blockade potentiates the stimulatory effect of L-DOPA on dopamine release in dopamine-deficient corticostriatal slice preparation.
The release of [3H]dopamine was measured in rat corticostriatal slice preparations that contained the striatum and the adjacent prefrontal cortex to maintained glutamatergic corticostriatalExpand
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Effects of 2,3-benzodiazepine AMPA receptor antagonists on dopamine turnover in the striatum of rats with experimental parkinsonism
Although levodopa is the current "gold standard" for treatment of Parkinson's disease, there has been disputation on whether AMPA receptor antagonists can be used as adjuvant therapy to improve theExpand
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Piperazine derivatives of alkyloxindoler
Changes in learning and memory after single and simultaneous lesion of the serotonergic and noradrenergic systems in the rat
Background Noradrenergic (NA) and serotonergic (5-HT) pathways play an inevitable role in several crucial central nervous system functions such as learning and memory, sleep, food-consumption andExpand
Derivatives of 3 - (((4-methylphenyl) -piperazin-1-yl) -alkyl) -3-alkyl-1,3-dihydro-2H-indol-2-one and the corresponding compounds for treating disorders Central Nervous System.
3,3-dialkyl derivatives indol-2-one of general formula (I): ** (See formula) ** in which: R1 represents hydrogen, halogen, alkyl having 1 to 7 carbon atoms or sulfonamido; R2 represents hydrogen orExpand