• Publications
  • Influence
Modeling familial Alzheimer's disease with induced pluripotent stem cells.
TLDR
It is found that FAD-iPSC-derived differentiated neurons have increased amyloid β42 secretion, recapitulating the molecular pathogenesis of mutant presenilins and indicating the potential for identification and validation of candidate drugs. Expand
[Modeling familial Alzheimer's disease with induced pluripotent stem cells].
TLDR
It is found that FAD-iPSC-derived differentiated neurons have increased toxic Aβ42 secretion, recapitulating the molecular pathogenesis of mutant presenilins, indicating the potential for identification and validation of candidate drugs. Expand
The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis
TLDR
NEAT1_2 lncRNA may act as a scaffold of RNAs and RNA binding proteins in the nuclei of ALS motor neurons, thereby modulating the functions of ALS-associated RNA-binding proteins during the early phase of ALS. Expand
Nuclear transport impairment of amyotrophic lateral sclerosis‐linked mutations in FUS/TLS
TLDR
This work examined the biochemical and cellular characteristics of mutant FUS in expressing cells and found that ALS‐linked mutations of FUS are clustered in the C‐terminal region. Expand
Characterization of the dipeptide repeat protein in the molecular pathogenesis of c9FTD/ALS.
TLDR
The present data indicate that a gain-of-function mechanism of toxic DRPs possibly contributes to pathogenesis in c9FTD/ALS and that DRPs may serve as novel therapeutic targets in c8FTD-ALS. Expand
Ambivalent Aspects of Interleukin-6 in Cerebral Ischemia: Inflammatory versus Neurotrophic Aspects
TLDR
Information suggests that IL-6 plays a double role in cerebral ischemia, as an inflammatory mediator during the acute phase and as a neurotrophic mediator between the subacute and prolonged phases. Expand
Origin and co‐localization of nitric oxide synthase, CGRP, PACAP, and VIP in the cerebral circulation of the rat
TLDR
The origin of perivascular nerve fibres storing nitric oxide synthase (NOS) and co‐localisation with periv vascular neuropeptides were examined in the rat middle cerebral artery by retrograde tracing with True Blue in combination with immunocytochemistry and indicates that the parasympathetic VIP‐, PACAP‐, and NOS‐immunoreactive nerve fibre originate from several sources. Expand
Distribution and origin of TRPV1 receptor-containing nerve fibers in the dura mater of rat
TLDR
The findings indicate that the TRPV1 receptor in the dura mater and sensory ganglia may contribute to the pathophysiology of migraine, providing an important clue for the development of therapeutic strategies for migraine. Expand
Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue
TLDR
These novel findings reveal mechanistic insights into the onset of PARK2 and identify novel targets for drug screening and potential modified therapies for PD. Expand
Clinical features and prognosis in anti-SRP and anti-HMGCR necrotising myopathy
TLDR
Anti-SRP antibodies are associated with severe neurological symptoms, more so than are anti-HMGCR antibodies, although these autoantibodies are independent serological markers associated with IMNM. Expand
...
1
2
3
4
5
...