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International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study
TLDR
The immunoscore provides a reliable estimate of the risk of recurrence in patients with colon cancer and supports the implementation of the consensus Immunoscore as a new component of a TNM-Immune classification of cancer. Expand
Fusobacterium nucleatum as a prognostic marker of colorectal cancer in a Japanese population
TLDR
The abundance of F. nucleatum in colorectal cancer tissues correlated with tumor size and KRAS mutation and was significantly associated with shorter overall survival times; this trend was notable in the patients with stage IV coloreCTal cancer. Expand
Differential expression of up-regulated cofilin-1 and down-regulated cofilin-2 characteristic of pancreatic cancer tissues.
TLDR
This is the first time that cofilin isoforms (cofilin-1/2) have been identified to be differentially expressed in pancreatic cancerous tissues and may serve as candidates for clinically useful biomarkers or therapeutic targets for PC. Expand
Expression of B7-H3, a Potential Factor of Tumor Immune Evasion in Combination with the Number of Regulatory T Cells, Affects Against Recurrence-Free Survival in Breast Cancer Patients
TLDR
It is demonstrated that expression of B7-H3 on tumor cells and the number of Tregs in the tumor microenvironment independently affected prognosis in breast cancer patients, suggesting that B7,H3 expression plays an independent role in tumor immune evasion, regardless of T Regs. Expand
Adoptive immunotherapy with MUC1-mRNA transfected dendritic cells and cytotoxic lymphocytes plus gemcitabine for unresectable pancreatic cancer
TLDR
AIT with M UC1-DCs and MUC1-CTLs plus GEM plus gemcitabine may be a feasible and effective treatment for pancreatic cancer. Expand
Efficacy of perioperative immunonutrition in esophageal cancer patients undergoing esophagectomy.
TLDR
Perioperative immunonutrition may improve early postoperative nutritional status and reduce postoperative infectious complications in patients with esophageal cancer undergoing esophagectomy. Expand
Overexpression of miR‑221 and miR‑222 in the cancer stroma is associated with malignant potential in colorectal cancer.
TLDR
The results suggested that the overexpression of miR‑221 and miR‐222 in the cancer stroma is associated with the metastatic activity and malignant potential in patients with CRC. Expand
Expression levels of UL16 binding protein 1 and natural killer group 2 member D affect overall survival in patients with gastric cancer following gastrectomy
TLDR
The interaction between ULBP1 and NKG2D may improve OS in patients with gastric cancer, and may have applications in immunotherapy for the induction of adaptive immunity in patientsWith cancer. Expand
Clinical implications of cancer stem cells in digestive cancers: acquisition of stemness and prognostic impact
TLDR
The prognostic potential of eight CSC markers, CD133, CD44, CD90, ALDH1A1, EPCAM,SOX2, SOX9, and LGR5, in digestive cancers including those of the pancreas, colon, liver, gastric, and esophagus are reviewed. Expand
A Phase I Clinical Trial of Vaccination With KIF20A-derived Peptide in Combination With Gemcitabine For Patients With Advanced Pancreatic Cancer
TLDR
Results suggest that this combination therapy will be feasible and promising for the treatment of advanced pancreatic cancer and IFN-&ggr;-producing cells were induced by the KIF20A-derived peptide vaccine at a high rate, even in combination with GEM. Expand
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