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NleC, a Type III Secretion Protease, Compromises NF-κB Activation by Targeting p65/RelA
- Hilo Yen, T. Ooka, A. Iguchi, Tetsuya Hayashi, N. Sugimoto, T. Tobe
- BiologyPLoS pathogens
- 1 December 2010
It is found that NleC is an anti-inflammatory bacterial zinc protease that disrupts NF-κB activation by the direct cleavage of NF-KKB's p65 subunit in the cytoplasm, thereby decreasing the available p65 and reducing the total nuclear entry of active p65.
Clostridium perfringens Enterotoxin Utilizes Two Structurally Related Membrane Proteins as Functional Receptors in Vivo *
- J. Katahira, H. Sugiyama, N. Inoue, Y. Horiguchi, M. Matsuda, N. Sugimoto
- BiologyThe Journal of Biological Chemistry
- 17 October 1997
The results indicate that CPE uses structurally related cellular proteins as functional receptors in vivo and that organs that have not so far been recognized as CPE-sensitive have the potential to be targets of CPE.
Molecular Cloning and Functional Characterization of the Receptor for Clostridium perfringens Enterotoxin
- J. Katahira, N. Inoue, Y. Horiguchi, M. Matsuda, N. Sugimoto
- BiologyThe Journal of cell biology
- 24 March 1997
It is proposed that the enterotoxin receptor is required for both target cell recognition and poreformation in the cell membrane.
Regulation of virulence by butyrate sensing in enterohaemorrhagic Escherichia coli.
- N. Nakanishi, K. Tashiro, S. Kuhara, T. Hayashi, N. Sugimoto, T. Tobe
- 1 February 2009
Upon entering the distal ileum, EHEC may respond to the higher butyrate level via Lrp by increasing its virulence expression, leading to efficient colonization of the target niche.
Human herpesvirus 6 open reading frame U12 encodes a functional beta-chemokine receptor.
It is suggested that the product of U12 may play an important role in the pathogenesis of HHV- 6 through transmembrane signaling by binding with beta-chemokines.
Activation of Motility by Sensing Short-Chain Fatty Acids via Two Steps in a Flagellar Gene Regulatory Cascade in Enterohemorrhagic Escherichia coli
EHEC first activates flagellar production and motility, followed by genes involved in adherence and type III secretion, which leads to efficient adherence in a preferable niche, when encountering increased concentrations of SCFAs in the intestine.
Dual regulatory pathways integrating the RcsC–RcsD–RcsB signalling system control enterohaemorrhagic Escherichia coli pathogenicity
LEE gene transcription may be regulated by RcsB through two oppositely regulated O157‐specific regulators, PchA and GrvA, which encodes a positive regulator for ler and abolished the effect of the rcsB deletion.
Bordetella bronchiseptica dermonecrotizing toxin stimulates assembly of actin stress fibers and focal adhesions by modifying the small GTP-binding protein rho.
- Y. Horiguchi, T. Senda, N. Sugimoto, J. Katahira, M. Matsuda
- BiologyJournal of cell science
- 1 October 1995
Results indicate that DNT causes the assembly of actin stress fibers and focal adhesions by directly modifying rho protein.
Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I.
This is the first report of an essential subcomponent of glycosyltransferases using dolichol-phosphate-monosaccharide, and it is found that Saccharomyces cerevisiae Pbn1p/YCL052Cp, which was previously reported to be involved in autoprocessing of proproteinase B, is the functional homologue of PIG-X.
ppGpp with DksA controls gene expression in the locus of enterocyte effacement (LEE) pathogenicity island of enterohaemorrhagic Escherichia coli through activation of two virulence regulatory genes
The adherence capacity of enterohaemorrhagic E. coli (EHEC) and gene expression in the locus of enterocyte effacement (LEE) were enhanced by a downshift in nutrients or by entry into the stationary growth phase, both of which increase the ppGpp concentration.