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Staging of Neurofibrillary Pathology in Alzheimer's Disease: A Study of the BrainNet Europe Consortium
It has been recognized that molecular classifications will form the basis for neuropathological diagnostic work in the future. Consequently, in order to reach a diagnosis of Alzheimer's disease (AD),… Expand
Genetic Creutzfeldt-Jakob disease associated with the E200K mutation: characterization of a complex proteinopathy
The E200K mutation is the most frequent prion protein gene (PRNP) mutation detected worldwide that is associated with Creutzfeldt-Jakob disease (CJD) and thought to have overlapping features with… Expand
Congenital hypothyroid Pax8(-/-) mutant mice can be rescued by inactivating the TRalpha gene.
Mice devoid of all TRs are viable, whereas Pax8(-/-) mice, which lack the follicular cells producing T4 and T3 in the thyroid gland, die during the first weeks of postnatal life. A precise comparison… Expand
Staging/typing of Lewy body related α-synuclein pathology: a study of the BrainNet Europe Consortium
When 22 members of the BrainNet Europe (BNE) consortium assessed 31 cases with α-synuclein (αS) immunoreactive (IR) pathology applying the consensus protocol described by McKeith and colleagues in… Expand
Assessment of β-amyloid deposits in human brain: a study of the BrainNet Europe Consortium
Abstractβ-Amyloid (Aβ) related pathology shows a range of lesions which differ both qualitatively and quantitatively. Pathologists, to date, mainly focused on the assessment of both of these aspects… Expand
The French series of autosomal dominant early onset Alzheimer's disease cases: mutation spectrum and cerebrospinal fluid biomarkers.
- D. Wallon, S. Rousseau, +25 authors D. Campion
- Biology, Medicine
- Journal of Alzheimer's disease : JAD
We describe 56 novel autosomal dominant early-onset Alzheimer disease (ADEOAD) families with PSEN1, PSEN2, and AβPP mutations or duplications, raising the total of families with mutations on known… Expand
A new mutation of the tau gene, G303V, in early-onset familial progressive supranuclear palsy.
BACKGROUND Progressive supranuclear palsy (PSP) is a clinicopathological syndrome related to tau deposits and in linkage disequilibrium with tau polymorphisms. Some rare familial PSP cases have been… Expand
Association of cerebrospinal fluid prion protein levels and the distinction between Alzheimer disease and Creutzfeldt-Jakob disease.
IMPORTANCE Although typical forms of Alzheimer disease (AD) and Creutzfeldt-Jakob disease (CJD) are clinically distinguishable, atypical AD phenotypes may pose a diagnostic challenge. The major… Expand
Predictive value of multimodality MRI using conventional, perfusion, and spectroscopy MR in anaplastic transformation of low-grade oligodendrogliomas
- C. Hlaihel, L. Guilloton, J. Guyotat, N. Streichenberger, J. Honnorat, F. Cotton
- Journal of Neuro-Oncology
- 1 March 2010
The aim of our study was to evaluate the role of proton magnetic resonance (MR) spectroscopy and MR perfusion in the follow-up of low-grade gliomas, since conventional MR imaging (MRI) is not… Expand
Diffusion Tensor–MRI Evidence for Extra-Axonal Neuronal Degeneration in Caudate and Thalamic Nuclei of Patients with Multiple Sclerosis
- Salem Hannoun, F. Durand-Dubief, +5 authors D. Sappey-Marinier
- American Journal of Neuroradiology
- 1 August 2012
BACKGROUND AND PURPOSE: MS is an inflammatory demyelinating disease affecting both WM and GM. While WM lesions are easily visualized by conventional MR imaging, the detection of GM alterations… Expand