• Publications
  • Influence
MEC-17 is an α-tubulin acetyltransferase
TLDR
It is shown that MEC-17, a protein related to the Gcn5 histone acetyltransferases and required for the function of touch receptor neurons in Caenorhabditis elegans, acts as a K40-specific acetyl transferase for α-tubulin. Expand
The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing.
TLDR
The degradation of p21 is defined as a critical aspect of replication licensing in human cells and is identified as a conserved role in degrading Cdt1. Expand
A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination.
TLDR
It is shown that TRA-1 is regulated by degradation mediated by a CUL-2-based ubiquitin ligase complex that contains FEM-1 as the substrate-recognition subunit, and F EM-2 and FEM3 as cofactors. Expand
Isolation and Characterization of Halotolerant Alkaliphilic Methanotrophic Bacteria from Tuva Soda Lakes
TLDR
The changes in cell phospholipids, fatty acids, and amino acids have been observed upon varying salinity and pH of the medium, thus suggesting structure-function osmoadaptation of the strains studied. Expand
Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors.
TLDR
Recent data is analyzed highlighting the current understanding of how distinct E3 pathways regulate subpopulations of the CKIs to control their diverse functions. Expand
The Caenorhabditis elegans cell‐cycle regulator ZYG‐11 defines a conserved family of CUL‐2 complex components
TLDR
It is shown that ZYG‐11 interacts with CUL‐2 in vivo and binds to the complex adaptor protein Elongin C using a nematode variant of the VHL‐box motif, and evidence that members of the extended ZyG11 family in nematodes and humans are conserved components of CUL2‐based ubiquitin‐ligases is provided. Expand
Circular box C/D RNAs in Pyrococcus furiosus.
TLDR
The unexpected discovery of circular box C/D RNAs in the rare biological form of RNA circles in the hyperthermophilic archaeon Pyrococcus furiosus points to the existence of a previously unrecognized biogenesis pathway for box C-DRNAs in archaea. Expand
The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage
TLDR
Balachandran et al. show that mitotic slippage occurs as a result of targeting of cyclin B1 for degradation by the ligase CRL2ZYG11. Expand
CRL2(LRR-1) targets a CDK inhibitor for cell cycle control in C. elegans and actin-based motility regulation in human cells.
TLDR
The CRL2(LRR-1) ubiquitin ligase is identified as a conserved regulator of Cip/Kip CKIs that promotes the degradation of C. elegans CKI-1 and human p21, acting as a critical regulator of cell motility that promotes a nonmotile stationary cell state by preventing p21 from inhibiting the Rho/ROCK/LIMK pathway. Expand
Overcoming Redundancy: An RNAi Enhancer Screen for Morphogenesis Genes in Caenorhabditis elegans
TLDR
This work presents a screen designed to uncover redundant and partially redundant genes that function in an example of morphogenesis, gastrulation in Caenorhabditis elegans, and shows that an RNAi-based enhancer screen in C. elegans can be used as an efficient means to identify important but redundant or partially redundant developmental genes. Expand
...
1
2
3
4
...