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Caveolae Localize Protein Kinase A Signaling to Arterial ATP-Sensitive Potassium Channels
Arterial ATP-sensitive K+ (KATP) channels are critical regulators of vascular tone, forming a focal point for signaling by many vasoactive transmitters that alter smooth muscle contractility and soExpand
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Comparative Pharmacology of Guinea Pig Cardiac Myocyte and Cloned hERG (IKr) Channel
Introduction: This study used whole‐cell, patch clamp techniques on isolated guinea pig ventricular myocytes and HEK293 cells expressing cloned human ether‐a‐go‐go‐related gene (hERG) to examine theExpand
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Angiotensin II-activated protein kinase C targets caveolae to inhibit aortic ATP-sensitive potassium channels.
OBJECTIVE The vasoconstrictor angiotensin II (Ang II) acts at G(q/11)-coupled receptors to suppress ATP-sensitive potassium (K(ATP)) channel activity via activation of protein kinase C (PKC). The aimExpand
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Isoform‐specific inhibition of voltage‐sensitive Ca2+ channels by protein kinase C in adrenal chromaffin cells
Selective protein kinase C (PKC) activators and inhibitors were used to investigate the involvement of specific PKC isoforms in the modulation of voltage‐sensitive Ca2+ channels (VSCCs) in bovineExpand
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ATP-sensitive potassium channels.
ATP-sensitive potassium (K(ATP)) channels link membrane excitability to metabolism. They are regulated by intracellular nucleotides and by other factors including membrane phospholipids, proteinExpand
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Voltage clamp techniques
Much of what we know about the properties of ion channels in cell membranes has come from experiments using voltage clamp. In general, the method allows ion flow across a cell membrane to be measuredExpand
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Cardiovascular biology: Tuning channels for blood pressure
Calcium ions are versatile messengers, helping to control many body functions including blood pressure. How they do this becomes clearer from a study of their interactions with ion channels in bloodExpand
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Separation and analysis of macroscopic currents
In voltage clamp experiments, ionic flow is measured as electrical current. Macroscopic currents recorded from whole cells, or from relatively large areas of cell membrane, represent the sum of theExpand
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17 Chapter 2 Voltage clamp techniques
Much of what we know about the properties of ion channels in cell membranes has come from experiments using voltage clamp. In general, the method allows ion flow across a cell membrane to be measuredExpand