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- Publications
- Influence
Potassium channels: Structure, classification, function and therapeutic potential
- N. Standen
- Medicine
- 1 October 1990
Caveolae Localize Protein Kinase A Signaling to Arterial ATP-Sensitive Potassium Channels
- Laura J Sampson, Y. Hayabuchi, N. Standen, C. Dart
- Biology, Medicine
- Circulation research
- 12 November 2004
Arterial ATP-sensitive K+ (KATP) channels are critical regulators of vascular tone, forming a focal point for signaling by many vasoactive transmitters that alter smooth muscle contractility and so… Expand
Comparative Pharmacology of Guinea Pig Cardiac Myocyte and Cloned hERG (IKr) Channel
- C. Davie, Jean Pierre-Valentin, +4 authors B. Thong
- Medicine
- Journal of cardiovascular electrophysiology
- 1 November 2004
Introduction: This study used whole‐cell, patch clamp techniques on isolated guinea pig ventricular myocytes and HEK293 cells expressing cloned human ether‐a‐go‐go‐related gene (hERG) to examine the… Expand
Angiotensin II-activated protein kinase C targets caveolae to inhibit aortic ATP-sensitive potassium channels.
- Laura J Sampson, L. M. Davies, R. Barrett-Jolley, N. Standen, C. Dart
- Biology, Medicine
- Cardiovascular research
- 1 October 2007
OBJECTIVE
The vasoconstrictor angiotensin II (Ang II) acts at G(q/11)-coupled receptors to suppress ATP-sensitive potassium (K(ATP)) channel activity via activation of protein kinase C (PKC). The aim… Expand
Isoform‐specific inhibition of voltage‐sensitive Ca2+ channels by protein kinase C in adrenal chromaffin cells
- C. Sena, R. M. Santos, N. Standen, M. Boarder, L. Rosário
- Chemistry, Medicine
- FEBS letters
- 9 March 2001
Selective protein kinase C (PKC) activators and inhibitors were used to investigate the involvement of specific PKC isoforms in the modulation of voltage‐sensitive Ca2+ channels (VSCCs) in bovine… Expand
ATP-sensitive potassium channels.
- G. Rodrigo, N. Standen
- Medicine
- Current pharmaceutical design
- 2005
ATP-sensitive potassium (K(ATP)) channels link membrane excitability to metabolism. They are regulated by intracellular nucleotides and by other factors including membrane phospholipids, protein… Expand
Voltage clamp techniques
- J. Halliwell, N. Standen
- 1999
Much of what we know about the properties of ion channels in cell membranes has come from experiments using voltage clamp. In general, the method allows ion flow across a cell membrane to be measured… Expand
- 11
- PDF
Cardiovascular biology: Tuning channels for blood pressure
- N. Standen
- Biology, Medicine
- Nature
- 19 October 2000
Calcium ions are versatile messengers, helping to control many body functions including blood pressure. How they do this becomes clearer from a study of their interactions with ion channels in blood… Expand
Separation and analysis of macroscopic currents
- N. Standen, N. Davies, P. Langton
- 1999
In voltage clamp experiments, ionic flow is measured as electrical current. Macroscopic currents recorded from whole cells, or from relatively large areas of cell membrane, represent the sum of the… Expand
- 2
- PDF
17 Chapter 2 Voltage clamp techniques
- J. Halliwell, T. Plant, J. Robbins, N. Standen
- 1999
Much of what we know about the properties of ion channels in cell membranes has come from experiments using voltage clamp. In general, the method allows ion flow across a cell membrane to be measured… Expand