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In vivo chlorpyrifos induced oxidative stress: Attenuation by antioxidant vitamins
Chlorpyrifos (O,O′-diethyl O-3,5,6-trichloro-2-pyridyl phosphorothionate, CPF) exposure in rats causes elevation in the levels of thiobarbituric acid reactive substances (TBARS) and inhibition ofExpand
Chlorpyrifos induced alterations in the levels of hydrogen peroxide, nitrate and nitrite in rat brain and liver
Abstract Organophosphate pesticides are among the most widely used synthetic chemicals for controlling a wide variety of pests. Chlorpyrifos (CPF) is among the leading organophosphate (OP) pesticidesExpand
Chlorpyrifos‐induced DNA damage in rat liver and brain
It can be concluded that CPF exhibits genotoxic potential in vivo, and exposure to CPF, acutely or chronically, caused a dose‐dependent increase in DNA damage in the liver and brain of rats. Expand
Effect of combined exposure of commonly used organophosphate pesticides on lipid peroxidation and antioxidant enzymes in rat tissues
Organophosphate compounds are among the most widely used synthetic chemicals for controlling a wide variety of pests. Organophosphate (OP) poisoning continues to be major cause of morbidity andExpand
Identification of differentially displayed proteins in cerebrospinal fluid of Parkinson's disease patients: a proteomic approach.
The results obtained suggest that differential display of CSF serum albumin precursor, serumalbumin chain-A, PRR 14 and serum transferrin N-terminal lobe could be associated with neuronal dysfunction and hemoglobin/globin with the onset/progression of PD in humans. Expand
Chloroquine efficacy studies confirm drug susceptibility of Plasmodium vivax in Chennai, India
Plasmodium vivax was found to be susceptible to CQ drug treatment in both the in vivo therapeutic drug study and the in vitro drug assay. Expand
Evaluation of micronuclei induction capacity and mutagenicity of organochlorine and organophosphate pesticides.
The genotoxic potential of all these four pesticides and mutagenic response of endosulfan and monocrotophos are shown and the suppression of proliferative activity of the bone marrow and increase in the extent of cell death are indicated. Expand
In vitro studies on organophosphate pesticides induced oxidative DNA damage in rat lymphocytes.
  • A. Ojha, N. Srivastava
  • Chemistry, Medicine
  • Mutation research. Genetic toxicology and…
  • 1 February 2014
This study studied the genotoxicity of the commonly used OP pesticides chlorpyrifos, methyl parathion, and malathion in Wistar rat peripheral blood lymphocytes in vitro to demonstrate genotoxic potential of these OP pesticides. Expand
Inferring the evolutionary history of Indian Plasmodium vivax from population genetic analyses of multilocus nuclear DNA fragments
The overall results indicated that Indian P. vivax bears high nucleotide diversity within population samples but moderate amount of genetic differentiation between population samples, and presents complex evolutionary history but possesses several features of being a part of ancestral distribution range of this species. Expand
Chlorpyrifos-induced alterations in rat brain acetylcholinesterase, lipid peroxidation and ATPases.
The effect of chlorpyrifos (O, O'-diethyl-3, 5, 6-trichloro-2-pyridyl phosphorothionate, CPF) exposure on acetylcholinesterase (AChE) activity, lipid peroxidation and different ATPases activities wasExpand