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Runx1 is required for the endothelial to hematopoietic cell transition but not thereafter
TLDR
It is shown by conditional deletion that Runx1 activity in vascular-endothelial-cadherin-positive endothelial cells is indeed essential for intra-arterial cluster, haematopoietic progenitor and HSC formation in mice. Expand
Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia
TLDR
The findings support a model for FPD/AML in which haploinsufficiency of CBFA2 causes an autosomal dominant congenital platelet defect and predisposes to the acquisition of additional mutations that cause leukaemia. Expand
Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.
TLDR
The CBFA2 (AML1) gene encodes a DNA-binding subunit of the heterodimeric core-binding factor, which significantly reduces the number of progenitors for erythroid and myeloid cells. Expand
Cbfa2 is required for the formation of intra-aortic hematopoietic clusters.
TLDR
It is shown that Cbfa2 is expressed in definitive hematopoietic progenitor cells, and in endothelial cells in sites from which these hematopolietic cells are thought to emerge. Expand
Core-binding factors in haematopoiesis and leukaemia
TLDR
Synergy between these convergent lines of enquiry has furthered the understanding of both normal and malignant haematopoiesis. Expand
Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.
TLDR
It is indicated that Runx1 deficiency has markedly different consequences during development compared with adult hematopoiesis, and insight into the phenotypic manifestations of Runx 1 deficiency in hematoietic malignancies is provided. Expand
Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo.
TLDR
Comparison with wild-type embryos showed that the distribution of HSCs among these various cell populations is sensitive to Runx1 dosage, which provides the first morphological description of embryonic H SCs and contribute new insight into their cellular origin. Expand
The CBFβ Subunit Is Essential for CBFα2 (AML1) Function In Vivo
TLDR
It is demonstrated that homozygous mutation of the Cbfb gene results in the same phenotype as the Cbfa2 gene and that the CBFβ subunit is required for CBFα2 function in vivo. Expand
Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor.
TLDR
It is proposed that CBF beta is a non-DNA-binding subunit of CBF and does not contact DNA directly and as a result decrease the rate of dissociation of the CBF protein-DNA complex. Expand
The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo.
TLDR
It is demonstrated that homozygous mutation of the Cbfb gene results in the same phenotype as Cbfa2, and the results demonstrate that the CBFbeta subunit is required for CBFalpha2 function in vivo. Expand
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