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Proteome profiling of immortalization‐to‐senescence transition of human breast epithelial cells identified MAP2K3 as a senescence‐promoting protein which is downregulated in human breast cancer
Purpose: Immortalization is one of the first changes in cells undergoing carcinogenic transformation. Proteome profiling of the immortalization–senescence transition is expected to provide insightsExpand
Elevated intraocular pressure, optic nerve atrophy, and impaired retinal development in ODAG transgenic mice.
PURPOSE In an earlier study, a cDNA was cloned that showed abundant expression in the eye at postnatal day (P)2 but was downregulated at P10; it was named ODAG (ocular development-associated gene).Expand
Proteomic study of DBA/2J mice retina: Down‐regulation of Integrin β7 correlated with retinal ganglion cell death
To identify and determine the function of the proteins associated with the death of retinal ganglion cells (RGCs) in DBA/2J mice, an animal model of glaucoma, retinas of DBA/2J mice, were analyzed byExpand
Proteome profiling of embryo chick retina
BackgroundLittle is known regarding the molecular pathways that underlie the process of retinal development. The purpose of this study was to identify proteins which may be involved in development ofExpand
Wnt14 inhibits death of retinal precursor cells.
An earlier proteomics study from our laboratory showed that Wnt14, a member of the Wnt family that regulates the development of vertebrates, was one of the proteins expressed transiently during theExpand
Proteomic Study of Retinal Proteins Associated with Transcorneal Electric Stimulation in Rats
Background. To investigate how transcorneal electric stimulation (TES) affects the retina, by identifying those proteins up- and downregulated by transcorneal electric stimulation (TES) in the retinaExpand
Proteomic Profiling of Diffuse Large B-Cell Lymphomas
Objective: The aim of this study was to identify differences in proteome profiles of diffuse large B-cell lymphoma (DLBCL) of nongerminal center (non-GC) versus GC type in the search for new markersExpand
Proteomic analyses of retina of excitatory amino acid carrier 1 deficient mice
BackgroundExcitatory amino acid carrier 1 (EAAC1) is a glutamate transporter found in neuronal tissues and is extensively expressed in the retina. EAAC1 plays a role in a variety of neural functions,Expand
Functional proteomics of failed filtering blebs
Purpose To identify and determine the function of the proteins associated with failed filtering blebs following trabeculectomy. Methods Tenon's tissues, obtained during surgery for failed filteringExpand
Acquisition of Invasiveness by Breast Adenocarcinoma Cells Engages Established Hallmarks and Novel Regulatory Mechanisms
Background/Aim: Proteomics of invasiveness opens a window on the complexity of the metastasis-engaged mechanisms. The extend and types of this complexity require elucidation. Materials and Methods:Expand