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Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects.
Existing evidence supporting a new concept that poor semen quality, testis cancer, undescended testis and hypospadias are symptoms of one underlying entity, the testicular dysgenesis syndrome (TDS), which may be increasingly common due to adverse environmental influences is summarized. Expand
The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration.
- A. Parent, G. Teilmann, A. Juul, N. Skakkebaek, J. Toppari, J. Bourguignon
- Medicine, Biology
- Endocrine reviews
- 1 October 2003
These observations urge further study of the onset of puberty as a possible sensitive and early marker of the interactions between environmental conditions and genetic susceptibility that can influence physiological and pathological processes. Expand
Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men.
High or low BMI was associated with reduced semen quality, and it remains to be seen whether the increasing occurrence of obesity in the Western world may contribute to an epidemic of poor semen quality registered in some of the same countries. Expand
Male reproductive health and environmental xenoestrogens.
- J. Toppari, J. C. Larsen, +16 authors N. Skakkebaek
- Biology, Medicine
- Environmental health perspectives
- 1 August 1996
The growing number of reports demonstrating that common environmental contaminants and natural factors possess estrogenic activity presents the working hypothesis that the adverse trends in male reproductive health may be, at least in part, associated with exposure to estrogenic or other hormonally active environmental chemicals during fetal and childhood development. Expand
Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?
It is argued that the increasing incidence of reproductive abnormalities in the human male may be related to increased oestrogen exposure in utero, and mechanisms by which this exposure could occur are identified. Expand
Environmental chemicals and thyroid function.
- M. Boas, U. Feldt-Rasmussen, N. Skakkebaek, K. Main
- European journal of endocrinology
- 1 May 2006
It is urgent to clarify whether the animal data showing effects of chemicals on thyroid function can be extended to humans, and especially fetal neurological development may be vulnerable. Expand
European consensus on diagnosis and treatment of germ cell cancer: a report of the European Germ Cell Cancer Consensus Group (EGCCCG).
- H. Schmoll, R. Souchon, +65 authors C. Wittekind
- Annals of oncology : official journal of the…
- 1 September 2004
Treatment decisions must be based on the available evidence which has been the basis for this consensus guideline delivering a clear proposal for diagnostic and treatment measures in each stage of gonadal and extragonadal germ cell tumour and individual clinical situations. Expand
Developmental expression of POU5F1 (OCT-3/4) in normal and dysgenetic human gonads.
- E. Rajpert-De Meyts, R. Hanstein, N. Jørgensen, N. Graem, P. Vogt, N. Skakkebaek
- Medicine, Biology
- Human reproduction
- 1 June 2004
In the human ovary, OCT-3/4 is silenced at the onset of the first meiotic prophase, whereas in the testis, down-regulation of OCT-4 is a gradual process associated with differentiation of gonocytes, which is disturbed in dysgenetic gonads, thus increasing the risk of malignant transformation. Expand
Carcinoma-in-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma.
- N. Skakkebaek, J. Berthelsen, A. Giwercman, J. Müller
- Biology, Medicine
- International journal of andrology
- 1 February 1987
Based on evidence from morphological and histochemical studies and from clinical experience, the following hypotheses are proposed: carcinoma-in-situ germ cells are malignant gonocytes; the pathogenesis of classical and spermatocytic seminoma are unrelated. Expand
Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society.
The importance of developmental stage and the realization that exposure to a presumptive "safe" dose of chemical may impact a life stage when there is normally no endogenous hormone exposure are emphasized, thereby underscoring the potential for very low-dose EDC exposures to have potent and irreversible effects. Expand