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Teratogenic effects in rabbits of simultaneous exposure to ochratoxin A and aflatoxin B1 with special reference to microscopic effects.
The results of the present study indicated that in combination, OTA and AFB1 have antagonistic interaction and microscopic examination of the fetal tissues could provide additional, useful information to a developmental toxicity study.
Effects of aflatoxin B1 on embryo fetal development in rabbits.
- P. Wangikar, P. Dwivedi, N. Sinha, A. Sharma, A. Telang
- Biology, MedicineFood and chemical toxicology : an international…
- 1 April 2005
The results of this study indicated that AFB1 was found to be teratogenic in rabbits when given by oral route during gestation days 6-18 and the dose of 0.1 mg/kg could be considered as the minimum oral Teratogenic dose.
Isoniazid induces oxidative stress, mitochondrial dysfunction and apoptosis in Hep G2 cells.
- S. Bhadauria, G. Singh, N. Sinha, S. Srivastava
- Chemistry, MedicineCellular and molecular biology
- 15 April 2007
It is concluded that INH induced apoptosis in Hep-G2 cells is mediated by generation of oxidative stress.
Pathogenicity of Mycobacterium tuberculosis Is Expressed by Regulating Metabolic Thresholds of the Host Macrophage
Whereas the requirement for macrophage survival sensitized TB susceptibility to the glycemic status of the individual, mediation by pathogen ensured that the virulence properties of the infecting strain also contributed towards the resulting pathology.
Therapeutic targets of triple‐negative breast cancer: a review
- V. Jamdade, N. Sethi, N. Mundhe, Parveen Kumar, M. Lahkar, N. Sinha
- MedicineBritish journal of pharmacology
- 1 September 2015
This review presents recent information associated with different therapeutic options for the treatment of TNBC focusing on promising targets such as the Notch signalling, Wnt/β‐catenin and Hedgehog pathways, in addition to EGFR, PARP1, mTOR, TGF‐β and angiogenesis inhibitors.
Prevalence of coronary artery disease, lower extremity peripheral arterial disease, and cerebrovascular disease in 110 men with an abdominal aortic aneurysm.
- R. Sukhija, W. Aronow, K. Yalamanchili, N. Sinha, S. Babu
- MedicineThe American journal of cardiology
- 15 November 2004
Of 110 men with an abdominal aortic aneurysm, 78 had coronary artery disease, 50 had lower extremity peripheral arterial disease, and 30 had cerebrovascular disease.
Effect in rats of simultaneous prenatal exposure to ochratoxin A and aflatoxin B1. II. Histopathological features of teratological anomalies induced in fetuses.
- P. Wangikar, P. Dwivedi, A. Sharma, N. Sinha
- Biology, MedicineBirth defects research. Part B, Developmental and…
- 1 December 2004
The present study indicates that the occurrence of brain, kidney, and liver lesions in combination treatment was less than in either individual treatment suggesting antagonism of OA-induced teratogenic effects by AFB1.
Dehydration-Induced Structural Changes in the Collagen–Hydroxyapatite Interface in Bone by High-Resolution Solid-State NMR Spectroscopy
Study of interactions among different components of amorphous biomaterial such as bone is important to understand the mechanism of its formation and biomineralization process and for its unique…
The Behavior of Water in Collagen and Hydroxyapatite Sites of Cortical Bone: Fracture, Mechanical Wear, and Load Bearing Studies.
- F. Gul-E-Noor, C. Singh, A. Papaioannou, N. Sinha, G. Boutis
- Chemistry, MedicineThe journal of physical chemistry. C…
- 17 September 2015
Reports on the dynamics, diffusion, population, and exchange of water in cortical bone by NMR relaxation and diffusion methodologies suggest that load bearing occurs largely in the collagen rich environment and is reversible.
Metabolic fingerprinting in breast cancer stages through 1H NMR spectroscopy‐based metabolomic analysis of plasma
- S. Suman, R. K. Sharma, Vijay Kumar, N. Sinha, Y. Shukla
- Medicine, ChemistryJournal of pharmaceutical and biomedical analysis
- 1 October 2018
Hydroxybutyrate, lysine, glutamate, glucose, lactate, and NAG levels were significantly altered with good biomarker potential in breast cancer and showed a good classifier for advanced stage breast cancer progression.