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The Influence of Parturition on the Level and Synthesis of Sulfated and Free Neurosteroids in Rats
Findings indicate an increase, not reflected in the brain cortex, in serum DHEA levels, at the end of pregnancy with a partial decrease following delivery and speculate that changes in the level or ratio of sulfated and free neurosteroids may play a role in postpartum behavioral disorders due to their antagonistic GABAA modulatory effect.
Improved survival of zygotes in superovulated rats following surgical or pharmacological block of ovarian steroid secretion
Test the hypothesis that the preimplantation losses of zygotes in pregnant superovulated juvenile rats was due to an imbalance of ovarian hormones and found that a lower dose reduced the recovery to the level of untreated animals, while increasing it to 60 mg resulted in maternal mortality and morbidity, as well as in developmental retardation ofZygotes.
Endothelin and sarafotoxin: influence on steroid-regulated motility of rat uterus.
Fetal Survival in the Rat as Affected by Intrauterine Injection of Serum Containing Antiphospholipid Antibodies
- R. Halperin, E. Hadas, N. Shinnar, I. Bukovsky, D. Schneider
- BiologyAmerican journal of reproductive immunology
- 1 November 2002
An experimental rat model is established, enabling to study the intrauterine effect of serum, containing antiphospholipid antibodies, in vivo, and to examine whether the detrimental effect of antiph phosphate-based antibodies on gestation is locally derived.
Effect of normal rat serum injected into the uterus on fetal survival in the rat
Human Decidua‐associated Protein 200 Neutralizes the Detrimental Effect of Serum Containing Antiphospholipid Antibodies on Fetal Survival in the Rat
- R. Halperin, N. Shinnar, N. Kronfeld-Schor, E. Hadas
- Biology, MedicineAmerican journal of reproductive immunology
- 1 April 2006
Whether the detrimental effect of serum containing antiphospholipid antibodies on rat pregnancy outcome can be neutralized by addition of human decidua‐associated protein (hDP) 200, a kind of rheumatoid factor, extracted from decidual tissue is examined.
ORIGINAL ARTICLE: Pathomorphologic and Immunohistochemical Study on the Devastation of Rat Embryos by Antiphospholipid Antibody Positive Serum
The aim was to examine the morphologic changes, induced in early rat embryos by intra‐uterine exposure to the low‐molecular weight fraction of boiled human serum containing antiphospholipid antibodies (APLA) that had been obtained from women with antiph phospholipids syndrome (APS).