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[The action of methandrostenolone and ecdysterone on the physical endurance of animals and on protein metabolism in the skeletal muscles].
The results of the comparative study on the myotropic activity of methandrostenolone and ecdysterone and their effects on physical endurance of animals suggested that ecdysterone possessing a widerExpand
Effect of progesterone and its synthetic analogues on the activity of mitochondrial permeability transition pore in isolated rat liver mitochondria.
Data indicate that buterol interacts with thiol groups, which explains its inhibitory effect not only on the mitochondrial pore but also on the transport system of xenobiotics in tumor cells in whichbuterol reduces the multidrug resistance. Expand
Role of mitochondrial thiols of different localization in the generation of reactive oxygen species
The role of thiols of the outer and the inner membranes of mitochondria in the regulation of generation of reactive oxygen species (ROS) has been studied. It was found that N-ethylmaleimide (NEM),Expand
[The complement-activating action of modern x-ray contrast agents].
The study conducted proved that triombrast (dose dependently) > hexabrics > Ultravist > or = melitrast = omnipac in a concentration interval of 0.03-30.0 mg iodine/ml in vitro and in a dose intervalExpand
The Atropomer Composition of Iopromide as an Indicator for Assessment of the Quality of its Substance and Medincal Formulations
The atropisomer composition of iopromide substance and formulations is discussed. At 120 °C in aqueous iopromide solution, its atropisomers were found to be converted to conformers, which reachedExpand
The Role of Phytoengineering in the Preparation and Production of Herbal Medicines
The opportunities provided by biotechnology and phytoengineering methods for producing physiologically active substances (secondary metabolites) of plant origin are considered. It is noted thatExpand
Thiol - Dependent Sensitization of Mitochondria and Tumor Cells to Doxorubicin
The problem of multidrug resistance has been intensively studied during the last decade. It is known that some synthetic progestins can chemosensitize tumor cells to cytostatic drugs; however, theExpand
[Antiproliferative and antioxidant activity of new dihydroquercetin derivatives].
There is a strong correlation (with a correlation coefficient of 0.93) between the antiproliferative effects of dihydroquercetin derivatives on murine skin fibroblasts and MCF-7 cells (human breast cancer). Expand
Effect of steroid hormones on production of reactive oxygen species in mitochondria
It was found that progesterone promoted formation of superoxide anion and hydrogen peroxide in mitochondria oxidizing the substrates of complex I of the respiratory chain but did not influence the production of ROS during oxidation of succinate, respiratory chain complex II substrate. Expand
Synthesis and Antiproliferative Activity of New Acylcatechins
New peracyl derivatives of the natural flavonoid (±)-catechin were synthesized. It was shown that carboxylic-acid acyl residues enhanced to various degrees the cytotoxicity of peracyl catechinsExpand