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Corin, a Mosaic Transmembrane Serine Protease Encoded by a Novel cDNA from Human Heart*
The chromosomal localization of the human corin gene makes it an attractive candidate gene for total anomalous pulmonary venous return and the unique domain structure and specific embryonic expression pattern suggest that corin may have a function in cell differentiation during development.
Functional Cloning of Src-like Adapter Protein-2 (SLAP-2), a Novel Inhibitor of Antigen Receptor Signaling
The identification of the negative regulator SLAP-2 demonstrates that a retroviral-based screening strategy may be an efficient way to identify and characterize the function of key components of many signal transduction systems.
Discovery and Characterization of Substituted Diphenyl Heterocyclic Compounds as Potent and Selective Inhibitors of Hepatitis C Virus Replication
It is found that R803 was more effective than alpha interferon (IFN-α) at blocking HCV RNA replication in the replicon model, and could potentially be developed as a treatment for HCV infection.
Active site labeling of HIV-1 reverse transcriptase.
The human immunodeficiency virus-1 reverse transcriptase (HIV-1 RT) heterodimer has been photoaffinity labeled using 4-thiodeoxyuridine triphosphate (S4-dUTP) as a probe.
Wheat germ and yeast RNA polymerase II: photoaffinity labeling by 4-thiouracil 5'-monophosphate positioned uniquely at the 3' end of an enzyme-bound [32P]-containing transcript.
A stable ternary transcription complex was formed with either wheat germ or yeast RNA polymerase II using a ribotrinucleotide primer (GpCpG) to initiate transcription on a short synthetic