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On the frequency of protein glycosylation, as deduced from analysis of the SWISS-PROT database.
The SWISS-PROT protein sequence data bank contains at present nearly 75,000 entries, almost two thirds of which include the potential N-glycosylation consensus sequence, or sequon, NXS/T (where X can… Expand
History of lectins: from hemagglutinins to biological recognition molecules.
The occurrence in nature of erythrocyte-agglutinating proteins has been known since the turn of the 19th century. By the 1960s it became apparent that such proteins also agglutinate other types of… Expand
Lectins: Carbohydrate-Specific Proteins That Mediate Cellular Recognition.
The purification, composition, and specificity of the anti-T lectin from peanut (Arachis hypogaea).
- R. Lotan, E. Skutelsky, D. Danon, N. Sharon
- Chemistry, Medicine
- The Journal of biological chemistry
- 10 November 1975
Peanut agglutinin was purified by affinity chromatography on Sepharose-epsilon-aminocaproyl-beta-D-galactopyranosylamine. The purified lectin obtained in a yield of 150 mg/100 g of defatted peanut… Expand
Legume lectins — a large family of homologous proteins
More than 70 lectins from leguminous plants belonging to different suborders and tribes have been isolated, mostly from seeds, and characterized to varying degrees. Although they differ in their… Expand
Carbohydrates as future anti-adhesion drugs for infectious diseases.
- N. Sharon
- Biology, Medicine
- Biochimica et biophysica acta
- 1 April 2006
Adhesion of pathogenic organisms to host tissues is the prerequisite for the initiation of the majority of infectious diseases. In many systems, it is mediated by lectins present on the surface of… Expand
Protein glycosylation. Structural and functional aspects.
During the last decade, there have been enormous advances in our knowledge of glycoproteins and the stage has been set for the biotechnological production of many of them for therapeutic use. These… Expand
Inhibitory activity of cranberry juice on adherence of type 1 and type P fimbriated Escherichia coli to eucaryotic cells.
- D. Zafriri, I. Ofek, R. Adar, M. Pocino, N. Sharon
- Biology, Medicine
- Antimicrobial Agents and Chemotherapy
- 1 January 1989
Inhibition of bacterial adherence to bladder cells has been assumed to account for the beneficial action ascribed to cranberry juice and cranberry juice cocktail in the prevention of urinary tract… Expand
The purification, composition and specificity of wheat-germ agglutinin.
1. The purification of wheat-germ agglutinin from commercial wheat germ is described. By ion-exchange chromatography three active proteins (isolectins) were separated, one of which was examined in… Expand
Lectins as cell recognition molecules.
Lectins on cell surfaces mediate cell-cell interactions by combining with complementary carbohydrates on apposing cells. They play a key role in the control of various normal and pathological… Expand