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History of lectins: from hemagglutinins to biological recognition molecules.
TLDR
A brief account of 100-plus years of lectin research is presented to show how these proteins have become the focus of intense interest for biologists and in particular for the glycobiologists among them.
Legume lectins — a large family of homologous proteins
  • N. Sharon, H. Lis
  • Biology, Chemistry
    FASEB journal : official publication of the…
  • 1 November 1990
TLDR
The location of the metal and carbohydrate binding sites, established unequivocally in concanavalin A by high resolution X‐ray crystallography, appears to be the same in the other legume lectins, opening the way for the application of molecular genetics to the investigation of the atomic structure of the carbohydrates binding sites of the lectins.
The Lectins: Properties, Functions and Applications in Biology and Medicine
TLDR
The study of interactions between lectins and immobilized the structure biology and application of documents animal lectins form function and clinical lectin from ricinus communis (castor bean) and the role of polyvalency in the mechanism of glyco recognition.
Protein glycosylation. Structural and functional aspects.
  • H. Lis, N. Sharon
  • Biology, Chemistry
    European journal of biochemistry
  • 15 November 1993
TLDR
Examples are given of changes that occur in the carbohydrates of soluble and cell-surface glycoproteins during differentiation, growth and malignancy, which further highlight the important role of these substances in health and disease.
Inhibitory activity of cranberry juice on adherence of type 1 and type P fimbriated Escherichia coli to eucaryotic cells
TLDR
Cranberry juice contains at least two inhibitors of lectin-mediated adherence of uropathogens to eucaryotic cells, and further studies are required to establish whether these inhibitors play a role in vivo.
The purification, composition and specificity of wheat-germ agglutinin.
TLDR
The purification of wheat-germ agglutinin from commercial wheat germ is described and it is proposed that the binding site consists of three or four subsites with differing specificities, in a cleft in the molecule resembling that for hen's-egg-white lysozyme.
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