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Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Large intervening non-coding RNAs (lincRNAs) are pervasively transcribed in the genome yet their potential involvement in human disease is not well understood. Recent studies of dosage compensation,Expand
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NF-κB-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia.
Cachexia is a debilitating condition characterized by extreme skeletal muscle wasting that contributes significantly to morbidity and mortality. Efforts to elucidate the underlying mechanisms ofExpand
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Pivotal trial of an autonomous AI-based diagnostic system for detection of diabetic retinopathy in primary care offices
Artificial Intelligence (AI) has long promised to increase healthcare affordability, quality and accessibility but FDA, until recently, had never authorized an autonomous AI diagnostic system. ThisExpand
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Visceral Adipose Inflammation in Obesity Is Associated with Critical Alterations in Tregulatory Cell Numbers
Background The development of insulin resistance (IR) in mouse models of obesity and type 2 diabetes mellitus (DM) is characterized by progressive accumulation of inflammatory macrophages andExpand
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Age related seroprevalence of antibodies to varicella in India.
OBJECTIVE To determine the age related prevalence of Varicella Zoster Virus (VZV) antibodies in India. SETTING This was a cross sectional multicentric study performed in 4 major cities of India:Expand
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Pathologic Response after Neoadjuvant Therapy is the Major Determinant of Survival in Patients with Esophageal Cancer
BackgroundEsophageal cancer remains a malignancy with high morbidity and mortality despite improvements to diagnosis, staging, chemotherapy, radiation, and surgery. Neoadjuvant therapy (NT) mayExpand
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Anticoagulation Monitoring during Pediatric Extracorporeal Membrane Oxygenation
The best method of monitoring anticoagulation during extracorporeal membrane oxygenation (ECMO) is unknown. We conducted a prospective observational study in a tertiary pediatric intensive care unit.Expand
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Radiation related morbidities and their impact on quality of life in head and neck cancer patients receiving radical radiotherapy
Although 50–70% of head and neck cancer patients in India receive radiotherapy (RT), radiation-related acute and late morbidities and their impact on quality of life (QOL) are infrequently reported.Expand
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HOXB13 mediates tamoxifen resistance and invasiveness in human breast cancer by suppressing ERα and inducing IL-6 expression.
Most breast cancers expressing the estrogen receptor α (ERα) are treated successfully with the receptor antagonist tamoxifen (TAM), but many of these tumors recur. Elevated expression of theExpand
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Should Clinicians Deliver Decision Aids? Further Exploration of the Statin Choice Randomized Trial Results
Background. Statin Choice is a decision aid about taking statins. The optimal mode of delivering Statin Choice (or any other decision aid) in clinical practice is unknown. Methods. To investigate theExpand
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