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- Publications
- Influence
Distinct Roles of Secreted HtrA Proteases from Gram-negative Pathogens in Cleaving the Junctional Protein and Tumor Suppressor E-cadherin*
- B. Hoy, T. Geppert, +9 authors S. Wessler
- Biology, Medicine
- The Journal of Biological Chemistry
- 15 February 2012
Background: The function of HtrA proteases in bacterial infections is widely unknown. Results: Secreted HtrA from various bacterial pathogens exhibits a conserved specificity for cleavage of… Expand
ADAM8 as a drug target in Pancreatic Cancer
- Uwe Schlomann, G. Koller, +19 authors J. Bartsch
- Medicine
- Nature communications
- 28 January 2015
Pancreatic ductal adenocarcinoma (PDAC) has a grim prognosis with less than 5% survivors after 5 years. High expression levels of ADAM8, a metalloprotease-disintegrin, are correlated with poor… Expand
Structure Elucidation of a Plant Metabolite of 4-Desoxynivalenol
- N. Sewald, J. L. V. Gleissenthall, M. Schuster, G. Mueller, R. Aplin
- Chemistry
- 1 July 1992
Abstract 3-β-D-Glucopyranosyl-4-desoxynivalenol, a glucoconjugate of the trichothecene 4-desoxynivalenol was isolated as main metabolite of DON from Zea mays suspension cultures. The structure was… Expand
Molecular mechanisms and kinetics between DNA and DNA binding ligands.
- A. Sischka, K. Toensing, +4 authors D. Anselmetti
- Chemistry, Medicine
- Biophysical journal
- 2005
Mechanical properties of single double-stranded DNA (dsDNA) in the presence of different binding ligands were analyzed in optical-tweezers experiments with subpiconewton force resolution. The binding… Expand
Identification of binding mechanisms in single molecule-DNA complexes.
- R. Eckel, R. Ros, Alexandra Ros, S. D. Wilking, N. Sewald, D. Anselmetti
- Materials Science, Chemistry
- Biophysical journal
- 1 September 2003
Changes in the elastic properties of single deoxyribonucleic acid (DNA) molecules in the presence of different DNA-binding agents are identified using atomic force microscope single molecule force… Expand
A Small Fibronectin-mimicking Protein from Bacteria Induces Cell Spreading and Focal Adhesion Formation*
- Nicole Tegtmeyer, R. Hartig, +7 authors S. Backert
- Biology, Medicine
- The Journal of Biological Chemistry
- 27 May 2010
Fibronectin, a 250-kDa eukaryotic extracellular matrix protein containing an RGD motif plays crucial roles in cell-cell communication, development, tissue homeostasis, and disease development. The… Expand
Anti-plasmodial and cholinesterase inhibiting activities of some constituents of Psorospermum glaberrimum.
- Bruno Ndjakou Lenta, K. Devkota, +6 authors N. Sewald
- Chemistry, Medicine
- Chemical & pharmaceutical bulletin
- 1 February 2008
Glaberianthrone (1), a new bianthrone was isolated from the hexane extract of the stem bark of Psorospermum glaberrimum together with thirteen known compounds: 3-geranyloxyemodin anthrone (2),… Expand
Antibacterial endiandric acid derivatives from Beilschmiedia anacardioides.
- Jean Rodolphe Chouna, Pepin Alango Nkeng-Efouet, +5 authors N. Sewald
- Biology, Medicine
- Phytochemistry
- 1 March 2009
Three endiandric acid derivatives, beilschmiedic acids A, B and C were isolated from the stem bark of Beilschmiedia anacardioides together with the known beta-sitosterol. Their structures were… Expand
Endiandric acid derivatives from the stem bark of Beilschmiedia anacardioides
- Jean Rodolphe Chouna, Pepin Alango Nkeng-Efouet, B. N. Lenta, J. D. Wansi, S. F. Kimbu, N. Sewald
- Chemistry
- 12 March 2010
Three new endiandric acid derivatives, beilschmiedic acids D, E and beilschmiedin were isolated from the stem bark of Beilschmiedia anacardioides together with the known compounds bisabolene and… Expand