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Distinct Roles of Secreted HtrA Proteases from Gram-negative Pathogens in Cleaving the Junctional Protein and Tumor Suppressor E-cadherin*
Background: The function of HtrA proteases in bacterial infections is widely unknown. Results: Secreted HtrA from various bacterial pathogens exhibits a conserved specificity for cleavage ofExpand
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Molecular systems biology
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ADAM8 as a drug target in Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) has a grim prognosis with less than 5% survivors after 5 years. High expression levels of ADAM8, a metalloprotease-disintegrin, are correlated with poorExpand
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Structure Elucidation of a Plant Metabolite of 4-Desoxynivalenol
Abstract 3-β-D-Glucopyranosyl-4-desoxynivalenol, a glucoconjugate of the trichothecene 4-desoxynivalenol was isolated as main metabolite of DON from Zea mays suspension cultures. The structure wasExpand
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Molecular mechanisms and kinetics between DNA and DNA binding ligands.
Mechanical properties of single double-stranded DNA (dsDNA) in the presence of different binding ligands were analyzed in optical-tweezers experiments with subpiconewton force resolution. The bindingExpand
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Identification of binding mechanisms in single molecule-DNA complexes.
Changes in the elastic properties of single deoxyribonucleic acid (DNA) molecules in the presence of different DNA-binding agents are identified using atomic force microscope single molecule forceExpand
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A Small Fibronectin-mimicking Protein from Bacteria Induces Cell Spreading and Focal Adhesion Formation*
Fibronectin, a 250-kDa eukaryotic extracellular matrix protein containing an RGD motif plays crucial roles in cell-cell communication, development, tissue homeostasis, and disease development. TheExpand
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Anti-plasmodial and cholinesterase inhibiting activities of some constituents of Psorospermum glaberrimum.
Glaberianthrone (1), a new bianthrone was isolated from the hexane extract of the stem bark of Psorospermum glaberrimum together with thirteen known compounds: 3-geranyloxyemodin anthrone (2),Expand
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Antibacterial endiandric acid derivatives from Beilschmiedia anacardioides.
Three endiandric acid derivatives, beilschmiedic acids A, B and C were isolated from the stem bark of Beilschmiedia anacardioides together with the known beta-sitosterol. Their structures wereExpand
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Endiandric acid derivatives from the stem bark of Beilschmiedia anacardioides
Three new endiandric acid derivatives, beilschmiedic acids D, E and beilschmiedin were isolated from the stem bark of Beilschmiedia anacardioides together with the known compounds bisabolene andExpand
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