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Design and self-assembly of two-dimensional DNA crystals
The design and observation of two-dimensional crystalline forms of DNA that self-assemble from synthetic DNA double-crossover molecules that create specific periodic patterns on the nanometre scale are reported.
Nucleic acid junctions and lattices.
- N. Seeman
- BiologyJournal of Theoretical Biology
- 21 November 1982
Sequence-specific recognition of double helical nucleic acids by proteins.
- N. Seeman, J. Rosenberg, A. Rich
- Biology, PhysicsProceedings of the National Academy of Sciences…
- 1 March 1976
It is concluded that a single hydrogen bond is inadequate for uniquely identifying any particular base pair, as this leads to numerous degeneracies, but using two hydrogen bonds, fidelity of base pair recognition may be achieved.
DNA in a material world
- N. Seeman
- 23 January 2003
The specific bonding of DNA base pairs provides the chemical foundation for genetics. This powerful molecular recognition system can be used in nanotechnology to direct the assembly of highly…
DNA double-crossover molecules.
It is concluded that the helices between parallel double crossovers must be shielded from each other or distorted from linearity if they are to participate in recombination and be catalyzed by topoisomerases if it occurs within the cell.
Synthesis from DNA of a molecule with the connectivity of a cube
This work reports the construction from DNA of a covalently closed cube-like molecular complex containing twelve equal-length double-helical edges arranged about eight vertices, the first construction of a closed polyhedral object from DNA.
Nanomaterials based on DNA.
- N. Seeman
- ChemistryAnnual Review of Biochemistry
- 9 June 2010
This work has shown that it is possible to construct novel DNA-based materials by combining these features in a self-assembly protocol by constructing polyhedrons, whose edges consist of double helical DNA and whose vertices correspond to the branch points.
Universal computation via self-assembly of DNA: Some theory and experiments
The computational capabilities inherent in the hybridization of DNA molecules are examined, and it is shown that the self-assembly of oligonucleotides into linear duplex DNA can only generate sets of sequences equivalent to regular languages.
A precisely controlled DNA biped walking device
An experimental realization of a molecular walking motor built from DNA, where psoralen molecules are attached to the ends of the feet in synthesis and cross-link strands covalently, allowing unambiguous determination of the state of the walker.
Crystalline two-dimensional DNA-origami arrays.
2D crystallization of origami tiles is reported to yield a 2D array with dimensions 2–3 microns on an edge, likely to be large enough to connect bottom-up methods of patterning with top-down approaches.