Author pages are created from data sourced from our academic publisher partnerships and public sources.
Share This Author
Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion.
Although a fraction of human blood memory CD4(+) T cells expresses chemokine (C-X-C motif) receptor 5 (CXCR5), their relationship to T follicular helper (Tfh) cells is not well established. Here we… Expand
Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination
- Salah-Eddine Bentebibel, Santiago M C Lopez, +14 authors H. Ueno
- Biology, Medicine
- Science Translational Medicine
- 13 March 2013
A T cell subset that emerges in blood after seasonal influenza vaccinations correlates with the development of protective antibody responses. What Lies Beneath Although the seasonal flu vaccine,… Expand
Phenotype and functions of memory Tfh cells in human blood.
Our understanding of the origin and functions of human blood CXCR5(+) CD4(+) T cells found in human blood has changed dramatically in the past years. These cells are currently considered to represent… Expand
Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12.
T follicular helper (Tfh) cells help development of antibody responses via interleukin-21 (IL-21). Here we show that activated human dendritic cells (DCs) induced naive CD4(+) T cells to become… Expand
The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells
Understanding the developmental mechanisms of follicular helper T cells (TFH cells) in humans is relevant to the clinic. However, the factors that drive the differentiation of human CD4+ helper T… Expand
Regulation of human helper T cell subset differentiation by cytokines.
Since the discovery of Th1 and Th2 cells in the late 1980s, the family of effector CD4(+) helper T (Th) cell subsets has expanded. The differentiation of naïve CD4(+) T cells is largely determined… Expand
Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers
- Salah-Eddine Bentebibel, N. Schmitt, J. Banchereau, H. Ueno
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 1 August 2011
T follicular helper (Tfh) cells represent a Th subset engaged in the help of B-cell responses in germinal centers (GCs). Tfh cells abundantly express the transcription repressor B-cell lymphoma 6… Expand
Targeting human dendritic cell subsets for improved vaccines.
Dendritic cells (DCs) were discovered in 1973 by Ralph Steinman as a previously undefined cell type in the mouse spleen and are now recognized as a group of related cell populations that induce and… Expand
IL-12 receptor β1 deficiency alters in vivo T follicular helper cell response in humans.
Antibody responses represent a key immune protection mechanism. T follicular helper (Tfh) cells are the major CD4(+) T-cell subset that provides help to B cells to generate an antibody response. Tfh… Expand
IL-7 Induces Immunological Improvement in SIV-Infected Rhesus Macaques under Antiviral Therapy1
Despite efficient antiretroviral therapy (ART), CD4+ T cell counts often remain low in HIV-1-infected patients. This has led to IL-7, a crucial cytokine involved in both thymopoiesis and peripheral T… Expand