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A randomized controlled trial of continuous positive airway pressure in mild obstructive sleep apnea.
TLDR
Nasal CPAP improved self-reported symptoms of OSA, including snoring, restless sleep, daytime sleepiness, and irritability, more than did placebo, but did not improve objective (Multiple Sleep Latency Test) or subjective (Epworth Sleepiness Scale) measures of daytimeSleepiness.
Nocturnal hypoxaemia and quality of sleep in patients with chronic obstructive lung disease.
TLDR
Hypoxaemia during sleep was related to waking values of SaO2 and PaCO2 but not to other daytime measures of lung function, and that the poorer a patient's arterial oxygenation throughout the night the more disturbed his sleep.
Effects of sustained and repetitive isocapnic hypoxia on ventilation and genioglossal and diaphragmatic EMGs.
TLDR
It is concluded that in awake normal male subjects SIH and RIH cause similar biphasic responses in VI and EMGdi activity, and mean EMGgg responses, however, differed.
Continuous positive airway pressure treatment improves pulmonary hemodynamics in patients with obstructive sleep apnea.
TLDR
CPAP treatment reduces Ppa and hypoxic pulmonary vascular reactivity in OSA and speculate that this may be due to improved pulmonary endothelial function.
A comparison of clinical assessment and home oximetry in the diagnosis of obstructive sleep apnea.
TLDR
It is concluded that home oximetry with CT90 < 1% practically excludes clinically significant OSA and home oxIMetry with DI > or = 15 for 4% desaturations makes OSA likely.
Estimation of the probability of disturbed breathing during sleep before a sleep study.
TLDR
Analysis of clinical features of patients presenting with suspected sleep apnea may reduce the need for sleep studies by about one-third yet still lead to the identification of the great majority of patients with abnormal breathing during sleep.
A community study of snoring and sleep-disordered breathing. Prevalence.
TLDR
A study of the prevalence of sleep-disordered breathing in subjects derived from a random sample of the population, which identified only male sex as an independent predictor of snoring without SDB and the independent predictors of SDB among snorers.
Urinary uric acid:creatinine ratio, serum erythropoietin, and blood 2,3-diphosphoglycerate in patients with obstructive sleep apnea.
TLDR
It is concluded that although urinary UA:Cr, serum EPO, and 2,3-DPG may be physiologically related to hypoxemia, none of these measures can be used to predict accurately the presence of moderate nocturnalhypoxemia in patients with OSA or in monitoring the effect of their therapy.
Activation of upper airway muscles before onset of inspiration in normal humans.
TLDR
It is concluded that a sequence of inspiratory muscle activation is present in humans and is more apparent during sleep and during CO2-induced hyperpnea than during wakefulness.
Effects of normal and loaded spontaneous inspiration on cardiovascular function.
TLDR
It is concluded that at least two factors affect aortic flow during inspiration: a decrease inleft ventricular preload that is associated with decreased left ventricular compliance, and increased impedance to left Ventricular emptying as reflected by the increase in aorti transmural pressure.
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