N. Saunders

Publications120
h-index44
Citations8,642
Highly Influential Citations479
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Complete genome sequence of Neisseria meningitidis serogroup B strain MC58.
TLDR
Neisseria meningitidis contains more genes that undergo phase variation than any pathogen studied to date, a mechanism that controls their expression and contributes to the evasion of the host immune system.
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GLK Transcription Factors Coordinate Expression of the Photosynthetic Apparatus in Arabidopsis[W][OA]
TLDR
It is shown that glk1 glk2 double mutants of Arabidopsis thaliana accumulate abnormal levels of chlorophyll precursors and that constitutive GLK gene expression leads to increased accumulation of transcripts for antenna proteins and chlorophyLL biosynthetic enzymes.
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Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing.
TLDR
The entire genome sequence of a virulent serogroup B strain was used to identify vaccine candidates and allowed the identification of proteins that are surface exposed, that are conserved in sequence across a range of strains, and that induce a bactericidal antibody response, a property known to correlate with vaccine efficacy in humans.
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CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms
TLDR
CD4+CD25+ regulatory T (TR) cells do not only suppress adaptive T cell responses, but are also able to control pathology mediated by innate immune mechanisms.
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Meningococcal Genetic Variation Mechanisms Viewed through Comparative Analysis of Serogroup C Strain FAM18
TLDR
Detailed view of novel genetic diversification mechanisms in N. meningitidis is provided, providing evidence for the hypothesis that the noncoding repeat arrays in neisserial genomes provide a crucial mechanism for the generation of surface antigen variants.
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ERF5 and ERF6 Play Redundant Roles as Positive Regulators of JA/Et-Mediated Defense against Botrytis cinerea in Arabidopsis
TLDR
Investigating the biological functions of two members of the less studied IXb subgroup of the ethylene response factor family in Arabidopsis thaliana suggests that ERF5 and ERF6 play positive but redundant roles in defense against B. cinerea and may also play a role in the antagonistic crosstalk between the JA/Et and SA signalling pathways.
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On the Origin of the Treponematoses: A Phylogenetic Approach
TLDR
The results lend support to the Columbian theory of syphilis's origin while suggesting that the non-sexually transmitted subspecies arose earlier in the Old World.
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The structure of CrgA from Neisseria meningitidis reveals a new octameric assembly state for LysR transcriptional regulators
TLDR
The crystal structures of both regulatory domain and full-length CrgA are reported, the first of a novel subclass of LTTRs that form octameric rings, and a model is proposed in which a hexadecameric array of two Cr gA oligomers binds to its DNA target site.
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The length of a tetranucleotide repeat tract in Haemophilus influenzae determines the phase variation rate of a gene with homology to type III DNA methyltransferases
TLDR
The number of repeats are demonstrated to be an important determinant of phase variation rate in H. influenzae for a gene containing a microsatellite.
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Expression of microRNAs in diffuse large B cell lymphoma is associated with immunophenotype, survival and transformation from follicular lymphoma
TLDR
It is suggested that microRNAs have potential as diagnostic and prognostic markers in these lymphomas and may be used to identify FCL patients at risk of high‐grade transformation.
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