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Contribution of each amino acid residue in polymyxin B(3) to antimicrobial and lipopolysaccharide binding activity.
This study on the structure-activity relationship of polymyxin B, a cyclic peptide antibiotic, used sixteen synthetic polymyxin B(3) analogs including alanine scanning analogs to elucidate theExpand
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Agonistic and antagonistic activities of neuromedin U-8 analogs substituted with glycine or D-amino acid on contractile activity of chicken crop smooth muscle preparations.
To study the structure-activity relationships of neuromedin U-8 (NMU-8) (H-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2) and to develop a NMU-8 antagonist, twenty-three NMU-8 analogs substituted with Gly orExpand
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Structure-activity relationships of neuromedin U. IV. Absolute requirement of the arginine residue at position 7 of dog neuromedin U-8 for contractile activity.
To examine the role of both Arg residues at positions 5 and 7 of dog neuromedin U-8 (d-NMU-8; pGlu1-Phe-Leu-Phe-Arg5-Pro-Arg7-Asn8-NH2) for smooth muscle contractile activity on isolated chickenExpand
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Kinetic properties of placental aminopeptidase A: N-terminal degradation of angiotensin II.
Purified placental aminopeptidase A cleaved N-terminal aspartic acid of Angiotensin II, and it was inhibited by amastatin. Amastatin and various angiotensin analogs having N-terminal dicarboxylicExpand
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Syntheses of C-peptides and Human Proinsulin
Syntheses of human, dog, rat, and duck C-peptides and their analogues and preliminary results on the total synthesis of human proinsulin are described. In the syntheses of the C-peptides, chainExpand
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The Contribution of the N-Terminal Structure of Polymyxin B Peptides to Antimicrobial and Lipopolysaccharide Binding Activity
To elucidate the N-terminal structure–activity relationships of polymyxin B peptides, seven polymyxin B component peptides, the structures of which having been elucidated, and seven N-terminal fatt...
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Contractile activity of porcine neuromedin U-25 and various neuromedin U-related peptide fragments on isolated chicken crop smooth muscle.
Contractile activity of porcine neuromedin U-25 (p-NMU-25) and various neuromedin U (NMU) peptide fragment amides was examined on chicken crop smooth muscle preparation. The relative activityExpand
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Structure-activity relationships of neuromedin U. I. Contractile activity of dog neuromedin U-related peptides on isolated chicken crop smooth muscle.
Synthetic dog neuromedin U-25(d-NMU-25), U-8(d-NMU-8) and their fragments wer examined for contractile activity on chicken crop smooth muscle preparation. The relative activities of d-NMU-25,Expand
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Bone-Targeting of Quinolones Conjugated with an Acidic Oligopeptide
PurposeOsteomyelitis is a progressive infectious process resulting in inflammatory destruction and necrosis of bone. The long-term administration of high-dosage antibiotics is required to treatExpand
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Toxic effect of a beta-amyloid peptide (beta 22-35) on the hippocampal neuron and its prevention.
A synthetic truncated beta-amyloid peptide, beta 22-35, was shown to have a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. The peptide formed aggregates andExpand
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