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Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C
The recommended treatment for patients with chronic hepatitis C, pegylated interferon-α (PEG-IFN-α) plus ribavirin (RBV), does not provide sustained virologic response (SVR) in all patients. We… Expand
A functional genomic screen identifies cellular cofactors of hepatitis C virus replication.
Hepatitis C virus (HCV) chronically infects 3% of the world's population, and complications from HCV are the leading indication for liver transplantation. Given the need for better anti-HCV… Expand
Remnants of the Early Solar System Water Enriched in Heavy Oxygen Isotopes
Oxygen isotopic composition of our solar system is believed to have resulted from mixing of two isotopically distinct nebular reservoirs, 16O-rich and 17,18O-rich relative to Earth. The nature and… Expand
Role of sarcolemmal KATP channels in cardioprotection against ischemia/reperfusion injury in mice
Recently it has been postulated that mitochondrial ATP-sensitive K+ (mitoKATP) channels rather than sarcolemmal KATP (sarcKATP) channels are important as end effectors and/or triggers of ischemic… Expand
Suppression of hepatitis C virus replication by cyclosporin a is mediated by blockade of cyclophilins.
BACKGROUND & AIMS Cyclosporin A specifically suppresses hepatitis C virus (HCV) replication in vitro at clinically achievable concentrations. In this study, we investigated the mechanisms of action… Expand
Antiviral effects of the interferon‐induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein
Interferons (IFNs) and the interferon‐stimulated genes (ISGs) play a central role in antiviral responses against hepatitis C virus (HCV) infection. We have reported previously that ISGs, including… Expand
Specific inhibition of hepatitis C virus replication by cyclosporin A.
- M. Nakagawa, N. Sakamoto, +10 authors M. Watanabe
- Biology, Medicine
- Biochemical and biophysical research…
- 2 January 2004
The difficulty in eradicating hepatitis C virus (HCV) infection is attributable to the limited treatment options against the virus. Recently, cyclosporin A (CsA), a widely used immunosuppressive… Expand
Role of sarcolemmal K(ATP) channels in cardioprotection against ischemia/reperfusion injury in mice.
Recently it has been postulated that mitochondrial ATP-sensitive K(+) (mitoK(ATP)) channels rather than sarcolemmal K(ATP) (sarcK(ATP)) channels are important as end effectors and/or triggers of… Expand
Ledipasvir and sofosbuvir fixed-dose combination with and without ribavirin for 12 weeks in treatment-naive and previously treated Japanese patients with genotype 1 hepatitis C: an open-label,…
BACKGROUND Compared with other countries, patients with chronic hepatitis C infection in Japan tend to be older, have more advanced liver disease, and are more likely to have been previously treated… Expand
Inhibition of intracellular hepatitis C virus replication by synthetic and vector‐derived small interfering RNAs
Small interfering RNAs (siRNAs) efficiently inhibit gene expression by RNA interference. Here, we report efficient inhibition, by both synthetic and vector‐derived siRNAs, of hepatitis C virus (HCV)… Expand