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Characterization of Mce4A protein of Mycobacterium tuberculosis: role in invasion and survival
BackgroundThe mce4 operon is one of the four homologues of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. The mce4A (Rv3499c) gene within this operon is homologous to mce1AExpand
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An insight into the regulation of mce4 operon of Mycobacterium tuberculosis.
The mce4 operon is reported to be involved in cholesterol utilization and intracellular survival of Mycobacterium tuberculosis (M. tuberculosis). The regulatory mechanism of this important operon wasExpand
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Revisiting a protocol for extraction of mycobacterial lipids.
Determination of lipid content of any biological sample is essential for various kinds of studies related to pathogenicity and drug development. Thus, reliable methods for the quantitative extractionExpand
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  • Open Access
Performance based Analysis of Wavelets Family for Image Compression-A Practical Approach
tl;dr
Proposed image compression method is implemented in frequency domain using wavelet transform.Image compression has become vital in today‟s scenario because lots of digital images has become spread over the servers which uses lots of space. Expand
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  • Open Access
Functional analysis of mce4A gene of Mycobacterium tuberculosis H37Rv using antisense approach.
Antisense strategy is an attractive substitute for knockout mutations created for gene silencing. mce genes have been shown to be involved in mycobacterial uptake and intracellular survival. Here weExpand
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  • Open Access
Mce4A protein of Mycobacterium tuberculosis induces pro inflammatory cytokine response leading to macrophage apoptosis in a TNF-α dependent manner.
Mycobacterium tuberculosis subverts the host immune response through numerous immune-evasion strategies. Apoptosis has been identified as one such mechanism and has been well studied in M.Expand
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Single nucleotide polymorphism in the genes of mce1 and mce4 operons of Mycobacterium tuberculosis: analysis of clinical isolates and standard reference strains
BackgroundThe presence of four mammalian cell entry (mce) operons in Mycobacterium tuberculosis suggests the essentiality of the functions of the genes in these operons. The differential expressionExpand
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The Mycobacterium tuberculosis recombinant LprN protein of mce4 operon induces Th-1 type response deleterious to protection in mice.
Lipoproteins are known to be effective immunogens and affect both innate and adaptive immunity. The lprN gene of Mycobacterium tuberculosis has been predicted to encode for a putative lipoprotein inExpand
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PDIM and SL1 accumulation in Mycobacterium tuberculosis is associated with mce4A expression.
Lipid metabolism forms the heart and soul of Mycobacterium tuberculosis life cycle. Starting from macrophage invasion at cholesterol rich micro-domains to a sustainable survival for infection byExpand
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Brugada-type electrocardiographic changes induced by fever.
A 54-year-old man who was admitted to the hospital with acute cholecystitis developed fever (40°C) and tachycardia. His medical history was significant for hypertension. An ECG revealed sinusExpand
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  • Open Access